Common use of Study No Clause in Contracts

Study No. 182253 Validation Of An HPLC Method For The Determination Of BA058 And PTH In Dose Formulations Price: Price: (with [*] % [*] discount) US$[*] US$21,850 * Please note that the above price is based on an estimated number of days of work to be performed. Should the estimate differ from the actual number of days needed, the Sponsor will be invoiced accordingly. Please also note that the Sponsor will be updated regularly on progress. Please sign and return this document via facsimile or email as soon as possible (contact information provided below). Should you have any questions or require any additional information, please do not hesitate to call me. We look forward to being of service. Best regards, ▇▇▇▇▇▇ ▇▇▇▇▇▇, MBA /s/ ▇.▇. ▇▇▇▇▇▇ Global Key Account Manager, Sales & Marketing Authorized Sponsor Representative ▇▇▇▇▇▇▇ River Laboratories Preclinical Services Montreal, Inc. 22022 Transcanadienne B.N. ▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇, ▇▇▇▇▇▇, ▇▇▇ ▇▇▇ Print (Name and Title) Phone: (▇▇▇) ▇▇▇-▇▇▇▇ Fax: (▇▇▇) ▇▇▇-▇▇▇▇ E-Mail: ▇▇▇▇▇▇.▇▇▇▇▇▇@▇▇▇.▇▇▇ Feb 11, 2009 Website: ▇▇▇.▇▇▇▇▇▇.▇▇▇ Date ▇▇▇▇▇▇▇ River * Confidential Treatment Requested by the Registrant. Redacted Portion Filed Separately with the Commission. 16 August 2010 ▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇, PhD VP, Biology RADIUS ▇▇▇ ▇▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇▇, ▇▇▇ ▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇, ▇▇ ▇▇▇▇▇ Phone: ▇▇▇.▇▇▇.▇▇▇▇ Email: ▇▇▇▇▇▇▇▇▇▇▇@▇▇▇▇▇▇▇▇▇▇▇.▇▇▇ Dear ▇▇. ▇▇▇▇▇▇▇▇▇▇, We thank you for your interest in ▇▇▇▇▇▇▇ River and hope the attached proposal meets with your approval. For your convenience, we have provided the following summary of the title and price of the studies and/or study components under discussion. If you would like us to proceed with animal orders resource allocation, sign and date the authorization line below. This price is valid for 60 days, but may be modified by mutual agreement if changes to the scope of work are made.

Study No. 182253 Validation Of An HPLC Method For The Determination Of BA058 And PTH In Dose Formulations Price: Price: (with [*] % [*] MPM discount) US$[*] US$21,850 * Please note that the above price is based on an estimated number of days of work to be performed. Should the estimate differ from the actual number of days needed, the Sponsor will be invoiced accordingly. Please also note that the Sponsor will be updated regularly on progress. Please sign and return this document via facsimile or email as soon as possible (contact information provided below). Should you have any questions or require any additional information, please do not hesitate to call me. We look forward to being of service. Best regards, ▇▇▇▇▇▇ ▇▇▇▇▇▇, MBA /s/ ▇.▇. ▇▇▇▇▇▇ Global Key Account Manager, Sales & Marketing Authorized Sponsor Representative ▇▇▇▇▇▇▇ River Laboratories Preclinical Services Montreal, Inc. 22022 Transcanadienne B.N. ▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇, ▇▇▇▇▇▇, ▇▇▇ ▇▇▇ Print (Name and Title) Phone: (▇▇▇) ▇▇▇-▇▇▇▇ Fax: (▇▇▇) ▇▇▇-▇▇▇▇ E-Mail: ▇▇▇▇▇▇.▇▇▇▇▇▇@▇▇▇.▇▇▇ Feb 11, 2009 Website: ▇▇▇.▇▇▇▇▇▇.▇▇▇ Date ▇▇▇▇▇▇▇ River * Confidential Treatment Requested by the Registrant. Redacted Portion Filed Separately with the Commission. 16 August 2010 ▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇, PhD VP, Biology RADIUS ▇▇▇ ▇▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇▇, ▇▇▇ ▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇, ▇▇ ▇▇▇▇▇ Phone: ▇▇▇.▇▇▇.▇▇▇▇ Email: ▇▇▇▇▇▇▇▇▇▇▇@▇▇▇▇▇▇▇▇▇▇▇.▇▇▇ Dear ▇▇. ▇▇▇▇▇▇▇▇▇▇, We thank you for your interest in ▇▇▇▇▇▇▇ River and hope the attached proposal meets with your approval. For your convenience, we have provided the following summary of the title and price of the studies and/or study components under discussion. If you would like us to proceed with animal orders resource allocation, sign and date the authorization line below. This price is valid for 60 days, but may be modified by mutual agreement if changes to the scope of work are made.

Study No. 182252 Set-Up And Pre-Validation Of An HPLC Method For The Determination Of BA058 And PTH In Dose Formulations Price: Price: (with [*] % MPM discount) Estimated 7-10 days* US$[*]/day US$[*]/day Study No. 182253 Validation Of An HPLC Method For The Determination Of BA058 And PTH In Dose Formulations Price: Price: (with [*] % [*] MPM discount) US$[*] US$21,850 * Please note that the above price is based on an estimated number of days of work to be performed. Should the estimate differ from the actual number of days needed, the Sponsor will be invoiced accordingly. Please also note that the Sponsor will be updated regularly on progress. Please sign and return this document via facsimile or email as soon as possible (contact information provided below). Should you have any questions or require any additional information, please do not hesitate to call me. We look forward to being of service. Best regards, ▇▇▇▇▇▇ ▇▇▇▇▇▇, MBA /s/ ▇.▇. ▇▇▇▇▇▇ Global Key Account Manager, Sales & Marketing Authorized Sponsor Representative ▇▇▇▇▇▇▇ River Laboratories Preclinical Services Montreal, Inc. 22022 Transcanadienne B.N. ▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇, ▇▇▇▇▇▇, ▇▇▇ ▇▇▇ Print (Name and Title) Phone: (▇▇▇) ▇▇▇-▇▇▇▇ Fax: (▇▇▇) ▇▇▇-▇▇▇▇ E-Mail: ▇▇▇▇▇▇.▇▇▇▇▇▇@▇▇▇.▇▇▇ Feb 11, 2009 Website: ▇▇▇.▇▇▇▇▇▇.▇▇▇ Date ▇▇▇▇▇▇▇ River * Confidential Treatment Requested by the Registrant. Redacted Portion Filed Separately with the Commission. [LETTERHEAD OF ▇▇▇▇▇▇▇ RIVER] accelerating drug development. exactly. Letter of Payment Authorization — Revision 1 16 August 2010 ▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇, PhD VP, Biology RADIUS ▇▇▇ ▇▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇▇, ▇▇▇ ▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇, ▇▇ ▇▇▇▇▇ Phone: ▇▇▇.▇▇▇.▇▇▇▇ Email: ▇▇▇▇▇▇▇▇▇▇▇@▇▇▇▇▇▇▇▇▇▇▇.▇▇▇ Dear ▇▇. ▇▇▇▇▇▇▇▇▇▇, We thank you for your interest in ▇▇▇▇▇▇▇ River and hope the attached proposal meets with your approval. For your convenience, we have provided the following summary of the title and price of the studies and/or study components under discussion. If you would like us to proceed with animal orders resource allocation, sign and date the authorization line below. This price is valid for 60 days, but may be modified by mutual agreement if changes to the scope of work are made.