Testing safety in CPP model apparatus Sample Clauses

Testing safety in CPP model apparatus. In the first milestone, we will determine 5-Methoxy-2-aminoindane (MEAI) anti-rewarding effect. MEAI was previously described as a recreational drug and binge drinking prevention drug1 2 3 4. Hence, we want to use a dose that will not be rewarding and addicted using Conditioned Place Preference (CPP) model. Usually, the rat will prefer to be more in the compartment that it received a reward in each conditioning day. If we want to prove MEAI as not rewarding agent, one would expect the rat not to prefer the compartment that is associated with MEAI. We will test two groups: One group will receive MEAI in each conditioning day, while the second group will receive cocaine each day. Additionally, some of the rats from the group that received cocaine will be treated with MEAI on the test day to determine if MEAI has a treatment-like effect.
Sample 1
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