Thiol concentration modification Sample Clauses

Thiol concentration modification. In chapters 3 and 4, agents which pharmacologically modify thiol concentration were used: diethyl maleate (DEM), buthionine sulphoximine (BSO) and N- acetylcysteine (NAC). DEM conjugates GSH in the presence of GSH-S- transferases and therefore depletes intracellular GSH pools147. BSO inhibits γ- glutamylcysteine synthetase which prevents GSH synthesis, thereby also depleting GSH concentration148. NAC is a cysteine derivative which contributes to the intracellular thiol pool and GSH synthesis149. NAC also directly replenishes GSH non-enzymatically by direct thiol exchange with GSSG.
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Related to Thiol concentration modification

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