Common use of WHAT NICE WILL PROVIDE Clause in Contracts

WHAT NICE WILL PROVIDE. The NICE team will: agree with the contractors a payment schedule (see Annex 4) provide the contractors with reference lists supplied by other contractor teams and those submitted in the call for evidence phase comment on and approve all materials (such as protocols, search strategies, screening checklists and amended quality assessment forms) used during the production of the review. provide the contractors with a copy of the flow diagram template for inclusion in the ‘Methods’ section of the evidence review comment on and approve the draft and final evidence reviews and the slides used for the presentation to the PDG meet with contractors at key points in the process (to be agreed) to agree next steps and to review progress provide a copy of appropriate disclaimer and funding text to be included in any journal publication issue an acceptance certificate once all the work has been delivered ANNEX 2 The Milestones Task Date to be Completed Contract commences LJMU submits draft review protocol for evidence review and any strategy for finding additional evidence NICE provides comments on draft evidence protocol and strategy Final evidence protocol and strategy agreed by LJMU and NICE team. LJMU begins searches Final screening checklists agreed by NICE and LJMU Progress review Draft Evidence review submitted NICE comments on evidence review Final evidence review submitted Papers sent to PHAC Slides for PHAC meeting PHAC 1 Changes to review post PHAC PHAC 2 LJMU assist the NICE team by clarifying any queries raised during the guidance consultation phase. 7 November 2012 13 November 2012 20 November 2012 27 November 2012 28 November 2012 7 December 2012 (TBA) 1 Feb 2013 29 March 2013 12 April 2013 17 May 2013 24 May 2013 31 May 2013 7 June 2013 24 June 2013 19 July 2013 December 2013 ANNEX 3 Waiver of Moral Rights and Assignment of Copyright This Deed is made the day of 2012

WHAT NICE WILL PROVIDE. The NICE team will: agree with the contractors a payment schedule (see Annex 4) provide the contractors with reference lists supplied by other contractor teams and those submitted in the call for evidence phase comment on and approve all materials (such as protocols, search strategies, screening checklists and amended quality assessment forms) used during the production of the review. provide the contractors with a copy of the flow diagram template for inclusion in the ‘Methods’ section of the evidence review comment on and approve the draft and final evidence reviews and the slides used for the presentation to the PDG meet with contractors at key points in the process (to be agreed) to agree next steps and to review progress provide a copy of appropriate disclaimer and funding text to be included in any journal publication issue an acceptance certificate once all the work has been delivered ANNEX 2 The Milestones Task Date to be Completed Contract commences LJMU submits draft review protocol for evidence review and any strategy for finding additional evidence NICE provides comments on draft evidence protocol and strategy Final evidence protocol and strategy agreed by LJMU and NICE team. LJMU begins NICE completes searches Final screening checklists agreed by NICE and LJMU Progress review Draft Evidence review submitted NICE comments on evidence review Final evidence review submitted Papers sent to PHAC Slides for PHAC meeting PHAC 1 Changes to review post PHAC PHAC 2 LJMU assist the NICE team by clarifying any queries raised during the guidance consultation phase. 7 November 2012 13 November 2012 20 November 2012 27 November 2012 28 November 2012 7 11 December 2012 (TBA) 11 December 2012 1 Feb 2013 29 March 2013 12 April 2013 17 May 2013 24 May 2013 31 May 2013 7 June 2013 24 June 2013 19 July 2013 December 2013 December013 ANNEX 3 Waiver of Moral Rights and Assignment of Copyright This Deed is made the day of 2012

WHAT NICE WILL PROVIDE. The NICE team will: agree with the contractors a payment schedule (see Annex 4) provide the contractors with reference lists supplied by other contractor teams and those submitted in the call for evidence phase comment on and approve all materials (such as protocols, search strategies, screening checklists and amended quality assessment forms) used during the production of the review. provide the contractors with a copy of the flow diagram template for inclusion in the ‘Methods’ section of the evidence review comment on and approve the draft and final evidence reviews and the slides used for the presentation to the PDG meet with contractors at key points in the process (to be agreed) to agree next steps and to review progress provide a copy of appropriate disclaimer and funding text to be included in any journal publication issue an acceptance certificate once all the work has been delivered ANNEX 2 The Milestones Task Date to be Completed Contract commences LJMU BCCEWH submits draft review protocol and search protocol/strategy for evidence review and any strategy for finding additional evidence NICE provides comments on draft evidence protocol and search protocol/strategy Final evidence protocol and search protocol/strategy agreed by LJMU BCCEWH and NICE team. LJMU BCCEWH begins searches BCCEWH submits draft title/abstract and full paper screening checklists NICE provides comments on draft screening checklists Final screening checklists agreed by NICE and LJMU Progress BCCEWH BCCEWH begins work on screening of papers Number of papers to be included in evidence review Draft (ready for data extraction and analysis) to be confirmed with NICE team. Evidence review submitted NICE comments on evidence review Final evidence review submitted Papers sent according to PHAC Slides for PHAC meeting PHAC 1 Changes to review post PHAC PHAC 2 LJMU table below BCCEWH assist the NICE team by clarifying any queries raised during the guidance consultation phase. 7 November 2012 13 November 29 March 2012 20 November April 2012 25 April 2012 End April 2012 4 May 2012 9 May 2012 14 May 2012 18 May 2012 28 May 2012 Various (from 11 June 2012 – 8 Feb 2013) October 2013 Details of evidence review section submission Task Section 1 Section 2 Section 3 Section 4 Section 5 Submission of draft evidence review section to NICE team: 11 June 2012 30 July 2012 14 Sept 2012 29 Oct 2012 10 Dec 2012 NICE provide comments on draft review section 18 June 2012 10 Aug 2012 21 Sept 2012 5 Nov 2012 18 Dec 2013 Submission of revised draft to NICE 4 July 2012 28 Aug 2012 8 Oct 2012 19 Nov 2012 9 Jan 2013 Draft mailed to PDG 9 July 2012 30 Aug 2012 11 Oct 2012 23 Nov 2012 11 Jan 2013 Submission of final slides for PDG 16 July 2012 5 Sept 2012 19 Oct 2012 3 Dec 2012 16 Jan 2013 Presentation of section at PDG meeting 23 July 2012* 11 Sept 2012 25 Oct 2012 6 Dec 2012 24 Jan 2013 Final amendments post PDG meeting 7 Aug 2012 27 November Sept 2012 28 November 9 Nov 2012 7 December 2012 (TBA) 1 11 Jan 2013 8 Feb 2013 29 March 2013 12 April 2013 17 May 2013 24 May 2013 31 May 2013 7 June 2013 24 June 2013 19 July 2013 December 2013 ANNEX 3 Waiver of Moral Rights and Assignment of Copyright This Deed is made the day of 2012

WHAT NICE WILL PROVIDE. The NICE team will: agree with the contractors a payment schedule (see Annex 4) provide the contractors with reference lists supplied by other contractor teams and those submitted in the call for evidence phase comment on and approve all materials (such as protocols, search strategies, screening checklists and amended quality assessment forms) used during the production of the review. provide the contractors with a copy of the flow diagram template for inclusion in the ‘Methods’ section of the evidence review comment on and approve the draft and final evidence reviews and the slides used for the presentation to the PDG meet with contractors at key points in the process (to be agreed) to agree next steps and to review progress provide a copy of appropriate disclaimer and funding text to be included in any journal publication issue an acceptance certificate once all the work has been delivered ANNEX 2 The Milestones Task Date to be Completed Contract commences LJMU LSHTM submits draft review protocol for evidence review and any strategy for finding additional evidence search protocol (including how to find grey literature and policy documents) NICE provides comments on draft evidence review protocol and strategy search protocol Final evidence review protocol and strategy agreed by LJMU LSHTM and NICE team. LJMU begins searches LSHTM & NICE develop and agree search strategy Final screening checklists agreed by NICE and LJMU Progress review LSHTM LSHTM finish database searches LSHTM finish grey lit searches Interviews with expert panel completed Draft Evidence review report(s) submitted NICE comments on evidence review Final evidence review submitted Papers sent to PHAC Slides for PHAC meeting PHAC 1 Changes to review post PHAC PHAC 2 LJMU LSHTM assist the NICE team by clarifying any queries raised during the guidance consultation phase. 7 November 2012 13 November 4 December 2012 11 December 2012 15 December 2012 20 November 2012 27 November 2012 28 November 2012 7 December 2012 (TBA) 1 Feb 20 December 2012 Mid January 2013 End January 2013 End January 2013 29 March 2013 12 April 2013 17 May 2013 24 May 2013 31 May 2013 7 June 2013 24 June 2013 19 July 2013 December 2013 ANNEX 3 Waiver of Moral Rights and Assignment of Copyright This Deed is made the day of 20122013

WHAT NICE WILL PROVIDE. The NICE team will: agree with Provide a Reference Manager/Endnote-compatible file of reference details of primary studies of potential relevance to the contractors a payment schedule (see Annex 4) provide evidence review that have been identified by the contractors with reference lists supplied by other contractor teams and those submitted in the call for evidence phase comment NICE team; Comment on and approve all materials (such as protocols, search strategies, screening checklists criteria and amended quality assessment forms) used during the production of the evidence review. provide the contractors with a copy of the flow diagram template for inclusion in the ‘Methods’ section of the evidence review comment ; Comment on and approve the draft and final evidence reviews review; Provide advice on NICE required processes and the slides used for the presentation to the PDG meet with contractors at key points in the process (to be agreed) to agree next steps methods, including checklists and to review progress provide forms; Provide a copy of appropriate disclaimer and funding text to be included in any journal publication issue if required; Issue an acceptance certificate once all the work has been delivered delivered. ANNEX 2 The Milestones Task Date to be Completed Contract commences LJMU completed Evidence review Start-up meeting between NICE team and University of Southampton 14th July 2014 University of Southampton submits draft evidence review protocol for evidence review and any search protocol/strategy for finding additional evidence 31st July 2014 NICE provides comments on draft evidence review protocol and search protocol/strategy 7th August 2014 Final evidence review protocol and search protocol/strategy agreed by LJMU NICE team and University of Southampton 12th August 2014 University of Southampton submits draft screening criteria 8th August 2014 NICE team. LJMU begins searches provides comments on draft screening criteria 12th August 2014 Final screening checklists criteria agreed by NICE team and LJMU Progress University of Southampton 14th August 2014 University of Southampton provide NICE with reference manager file results of any references for the economic analysis and modelling report 26th September 2014 University of Southampton sends draft evidence review Draft Evidence review submitted to NICE team for comment 21st October 2014 (midday) NICE team provides comments on draft evidence review Final 27th October 2014 Meeting between NICE team and University of Southampton to discuss draft evidence review, NICE team comments and agree revisions TBC University of Southampton submit revised draft evidence review submitted Papers sent to PHAC Slides for PHAC meeting PHAC 1 Changes to review post PHAC PHAC 2 LJMU assist the NICE team by clarifying ready for committee mailing 3rd November 2014 NICE team mail evidence review to SSAC 5th November 2014 University of Southampton to submit PowerPoint slides to NICE team in preparation for committee meeting 11th November 2014 University of Southampton attend and present evidence review to SSAC 13th November 2014 University of Southampton undertake any required revisions post SSAC and submit final evidence review prior to draft guideline consultation phase 28th November 2014 University of Southampton provide clarification, if required, to any stakeholder queries raised during on the guidance evidence review published as part of the guideline consultation phaseFebruary 2015 The above three activities and dates highlighted in yellow will inform the payment plan detailed in Annex 4. 7 November 2012 13 November 2012 20 November 2012 27 November 2012 28 November 2012 7 December 2012 (TBA) 1 Feb 2013 29 March 2013 12 April 2013 17 May 2013 24 May 2013 31 May 2013 7 June 2013 24 June 2013 19 July 2013 December 2013 Payments will be tied to deliverables. ANNEX 3 Waiver NOT APPLICABLE ANNEX 4 Payment Specify amount of Moral Rights payment for the Services (including or excluding VAT), timing and Assignment method of Copyright This Deed is made the day payment. Amount of 2012Funding Financial Year Date(s) for Submission of Invoice(s) GRAND TOTAL £54,516.75 £65,420.10 (including VAT)