Acambis PLC Sample Contracts

ARTICLE I COVENANTS, REPRESENTATIONS AND ACKNOWLEDGEMENTS OF LIMITED
License Agreement • April 9th, 1999 • Peptide Therapeutics Group PLC • Pharmaceutical preparations • New York
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2) NICOLAS HIGGINS ---------------------------- DIRECTOR'S SERVICE AGREEMENT ----------------------------
Service Agreement • February 10th, 1999 • Peptide Therapeutics Group PLC • England
and PEPTIMMUNE INC.
Agreement • April 9th, 1999 • Peptide Therapeutics Group PLC • Pharmaceutical preparations • England
NOVARTIS PHARMA AG COLLABORATION AGREEMENT
Agreement • April 9th, 1999 • Peptide Therapeutics Group PLC • Pharmaceutical preparations • England and Wales
ARTICLE I PMC STANDSTILL
Standstill Agreement • January 28th, 1999 • Peptide Therapeutics Group PLC • Biological products, (no disgnostic substances) • New York
LETTERHEAD]
Peptide Therapeutics Group PLC • March 18th, 1999 • Pharmaceutical preparations
ELI LILLY AND COMPANY COLLABORATION AGREEMENT
Collaboration Agreement • April 9th, 1999 • Peptide Therapeutics Group PLC • Pharmaceutical preparations • England
LETTERHEAD]
Peptide Therapeutics Group PLC • April 9th, 1999 • Pharmaceutical preparations

This letter is intended to outline the general terms which have been agreed between Peptide Therapeutics ("PT") and the joint ventures between OraVax, Inc. and Pasteur Merieux Serums et Vaccins S.A. known as Merieux OraVax S.N.C. and OraVax Merieux Co. ("PM-O").

and PEPTIMMUNE INC.
Agreement • March 30th, 1999 • Peptide Therapeutics Group PLC • Pharmaceutical preparations • England
RECITALS
Stockholder Voting Agreement • November 20th, 1998 • Peptide Therapeutics Group PLC • Biological products, (no disgnostic substances) • Massachusetts
ORAVAX, INC.
Stock Purchase Agreement • November 20th, 1998 • Peptide Therapeutics Group PLC • Biological products, (no disgnostic substances) • Delaware
CONFIDENTIAL
D and License Agreement • April 9th, 1999 • Peptide Therapeutics Group PLC • Pharmaceutical preparations • England
and-
Assignment and Variation Agreement • April 9th, 1999 • Peptide Therapeutics Group PLC • Pharmaceutical preparations • Maryland
ACAMBIS PLC LETTERHEAD]
Acambis PLC • June 28th, 2006 • Pharmaceutical preparations

Following our review of the terms of appointment for Board members, the purpose of this letter (the “Agreement”) is formally to confirm the updated terms of your appointment as a Non-executive Director of Acambis (the “Company”).

Contract
Agency and Development Agreement • June 28th, 2004 • Acambis PLC • Pharmaceutical preparations • England

Confidential treatment has been requested for certain portions of this exhibit. The copy filed herewith omits the information subject to the confidential treatment request. Omissions are designated as " ***** ". A complete version of this exhibit has been filed separately with the Commission pursuant to an application for confidential treatment under Rule 24b-2 promulgated under the Securities Exchange Act of 1934, as amended.

AMENDMENT NO. 1
Peptide Therapeutics Group PLC • March 18th, 1999 • Pharmaceutical preparations
SUBSCRIPTION AGREEMENT between PEPTIDE THERAPEUTICS GROUP plc and BAXTER INTERNATIONAL INC. Weil, Gotshal & Manges
Subscription Agreement • July 16th, 2003 • Acambis PLC • Pharmaceutical preparations
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EXHIBIT 4 AGREEMENT AS TO JOINT FILING OF SCHEDULE 13D Each of the undersigned hereby affirms that it is individually eligible to use Schedule 13D, and agrees that this Schedule 13D is filed on its behalf. Date: November 20, 1998 PEPTIDE THERAPEUTICS...
Peptide Therapeutics Group PLC • November 20th, 1998 • Biological products, (no disgnostic substances)

Each of the undersigned hereby affirms that it is individually eligible to use Schedule 13D, and agrees that this Schedule 13D is filed on its behalf.

FIRST AMENDMENT TO SUBLEASE
Sublease • July 16th, 2003 • Acambis PLC • Pharmaceutical preparations • Massachusetts

THIS FIRST AMENDMENT TO SUBLEASE (the “Amendment”), dated as of April 16, 2003 between BAXTER CAPITAL CORPORATION, a Delaware corporation (“Sublessor”), and ACAMBIS, INC., a Delaware corporation (“Sublessee”).

DISTRIBUTION, MANUFACTURING, AND LICENSE AGREEMENT
Acambis PLC • April 1st, 2005 • Pharmaceutical preparations • England and Wales

This Distribution, Manufacturing, and License Agreement is entered into at the date of countersignature (the “Effective Date”) by and between Acambis Research Limited, Peterhouse Technology Park, 100 Fulbourn Road, Cambridge CB1 9PT UK (“Acambis Research”) and Baxter Healthcare SA, having offices at Hertistrasse 2, CH-8304 Wallisellen, Switzerland (“BHSA”) and Baxter Healthcare Corporation, having offices at One Baxter Parkway, Deerfield, IL 60015 (“BHC”).

SUBLEASE Dated as of December 21, 2001 Between BAXTER CAPITAL CORPORATION, as the Sublessor, and ACAMBIS, INC. as the Sublessee.
Sublease • July 16th, 2003 • Acambis PLC • Pharmaceutical preparations • Massachusetts
DISTRIBUTION AGREEMENT
Distribution Agreement • June 28th, 2004 • Acambis PLC • Pharmaceutical preparations

THIS DISTRIBUTION AGREEMENT (the “Agreement”) is made and entered into as of the 28th day of June, 2001 (referred to in this Agreement as the “Commencement Date”), by and between BERNA BIOTECH LTD. (former: BERNA SCHWEIZERISCHES SERUM UND IMPFINSTITUT), a corporation organized and existing under the laws of Switzerland (hereinafter referred to as “Seller”), and BERNA PRODUCTS CORP., a corporation organized and existing under the laws of the State of Delaware, United States (hereinafter referred to as “Distributor”).

DISTRIBUTION, MANUFACTURING, AND LICENSE AGREEMENT
Acambis PLC • July 16th, 2003 • Pharmaceutical preparations • England and Wales

This Distribution, Manufacturing, and License Agreement is entered into at the date of countersignature (the “Effective Date”) by and between Acambis Research Limited, Peterhouse Technology Park, 100 Fulbourn Road, Cambridge CB1 9PT UK (“Acambis Research”) and Baxter Healthcare SA, having offices at Hertistrasse 2, CH-8304 Wallisellen, Switzerland (“BHSA”) and Baxter Healthcare Corporation, having offices at One Baxter Parkway, Deerfield, IL 60015 (“BHC”).

CONTRACT MANUFACTURING AGREEMENT between (1) BAXTER HEALTHCARE CORPORATION (2) BAXTER HEALTHCARE S.A. (3) ORAVAX INC. (4) PEPTIDE THERAPEUTICS GROUP PLC
Contract Manufacturing Agreement • July 16th, 2003 • Acambis PLC • Pharmaceutical preparations • Delaware
ACAMBIS PLC LETTERHEAD]
Acambis PLC • June 28th, 2006 • Pharmaceutical preparations

Subject to Clause 9 your appointment as a Non-executive Director will commence on the above date and will continue until 1 September 2006 (Termination Date).

Contract
Acambis PLC • June 28th, 2004 • Pharmaceutical preparations

Confidential treatment has been requested for certain portions of this exhibit. The copy filed herewith omits the information subject to the confidential treatment request. Omissions are designated as " ***** ". A complete version of this exhibit has been filed separately with the Commission pursuant to an application for confidential treatment under Rule 24b-2 promulgated under the Securities Exchange Act of 1934, as amended.

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