Kubota Ryo Sample Contracts

English Translation] VOTING AGREEMENT
Voting Agreement • February 24th, 2015 • Kubota Ryo • Pharmaceutical preparations

This Voting Agreement (this “Agreement”) is made and entered into as of February 20, 2015 (the “Date”), by and between Yoshitaka Kitao (“Kitao”), and (ii) Dr. Ryo Kubota (“Dr. Kubota,” and Kitao and Dr. Kubota collectively, the “Parties”).

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AGREEMENT REGARDING JOINT FILING OF STATEMENT ON SCHEDULE 13D
Joint Filing Agreement • February 24th, 2015 • Kubota Ryo • Pharmaceutical preparations

Each of the undersigned hereby acknowledges and agrees, pursuant to the provisions of Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, that the Schedule 13D to which this Agreement is attached as an Exhibit, and any amendments thereto, will be filed with the Securities and Exchange Commission jointly on behalf of the undersigned.

Translation] TERMINATION AGREEMENT
Termination Agreement • May 14th, 2015 • Kubota Ryo • Pharmaceutical preparations

This Termination Agreement (this “Termination Agreement”) is entered into as of May 13, 2015 (the “Date”), by and between Yoichi Tsuchiya (“Tsuchiya”) and Ryo Kubota (“Kubota,” and Tsuchiya and Kubota collectively, the “Parties”).

English Translation] VOTING AGREEMENT
Voting Agreement • February 24th, 2015 • Kubota Ryo • Pharmaceutical preparations

This Voting Agreement (this “Agreement”) is made and entered into as of February 20, 2015 (the “Date”), by and between Hikaru Shimura (“Shimura”), and (ii) Dr. Ryo Kubota (“Dr. Kubota,” and Shimura and Dr. Kubota collectively, the “Parties”).

Translation] TERMINATION AGREEMENT
Termination Agreement • May 14th, 2015 • Kubota Ryo • Pharmaceutical preparations

This Termination Agreement (this “Termination Agreement”) is entered into as of May 13, 2015 (the “Date”), by and between Yoshitaka Kitao (“Kitao”) and Ryo Kubota (“Kubota,” and Kitao and Kubota collectively, the “Parties”).

VOTING AGREEMENT AND IRREVOCABLE PROXY
Voting Agreement and Irrevocable Proxy • February 2nd, 2015 • Kubota Ryo • Pharmaceutical preparations • Washington

This Voting Agreement and Irrevocable Proxy (this “Agreement”), is made as of the 28 day of January, 2015, by and among Ryo Kubota, an individual (“Kubota”), and each of the undersigned Shareholders (“Shareholders”) of Acucela Inc., a Washington corporation (the “Company”).

MUTUAL TERMINATION AGREEMENT
Mutual Termination Agreement • May 14th, 2015 • Kubota Ryo • Pharmaceutical preparations • Washington

This MUTUAL TERMINATION AGREEMENT (the “Termination Agreement”) is entered into as of May 13, 2015 (the “Effective Date”), by and among Ryo Kubota, an individual (“Kubota”), and each of the undersigned shareholders (“Shareholders”) of Acucela Inc., a Washington corporation (the “Company”).

Translation] TERMINATION AGREEMENT
Termination Agreement • May 14th, 2015 • Kubota Ryo • Pharmaceutical preparations

This Termination Agreement (this “Termination Agreement”) is entered into as of May 13, 2015 (the “Date”), by and between Hikaru Shimura (“Shimura”) and Ryo Kubota (“Kubota,” and Shimura and Kubota collectively, the “Parties”).

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