Shin Nippon Biomedical Laboratories, Ltd. Sample Contracts

Further Deed of Charge of Shares Dated 15 May 2019 Between (each referred to as a Party and collectively as the Parties). Recitals
Shin Nippon Biomedical Laboratories, Ltd. • August 12th, 2022 • Pharmaceutical preparations

A Wave Life Sciences Ltd. (Registration No. 201218209G) (WAVE) is a company incorporated under the laws of Singapore and having its registered office at 8 Cross Street, #10-00, PWC Building, Singapore 048424.

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THIRD AMENDMENT TO PLEDGE AGREEMENT
Pledge Agreement • February 20th, 2019 • Shin Nippon Biomedical Laboratories, Ltd. • Pharmaceutical preparations • Washington

THIS THIRD AMENDMENT TO PLEDGE AGREEMENT is dated as of June 27, 2018 (this “Amendment”) and is made by and between SNBL U.S.A. Ltd., a Washington corporation (“SNBL USA”) and The Kagoshima Bank, Ltd. (“Lender”).

CONTINGENT VALUE RIGHTS AGREEMENT between SHIN NIPPON BIOMEDICAL LABORATORIES, LTD., and AMERICAN STOCK TRANSFER & TRUST COMPANY, LLC, as the Rights Agent Dated as of June 6, 2023
Contingent Value Rights Agreement • June 8th, 2023 • Shin Nippon Biomedical Laboratories, Ltd. • Pharmaceutical preparations • Delaware

THIS CONTINGENT VALUE RIGHTS AGREEMENT, dated as of June 6, 2023 (this “Agreement”), is entered into between Shin Nippon Biomedical Laboratories, Ltd., a Japanese corporation (“Parent”) and AMERICAN STOCK TRANSFER & TRUST COMPANY, LLC, as Rights Agent (the “Rights Agent”).

STOCK PLEDGE AGREEMENT
Stock Pledge Agreement • April 26th, 2018 • Shin Nippon Biomedical Laboratories, Ltd. • Pharmaceutical preparations • Washington

This STOCK PLEDGE AGREEMENT, dated as of December 28, 2016 (as amended, supplemented or otherwise modified from time to time in accordance with the provisions hereof, this “Agreement”), made by and between SNBL U.S.A., Ltd., a Washington corporation (the “Pledgor”) and The Kagoshima Bank, Ltd., a Japanese banking corporation (the “Secured Party”).

Deed of Charge of Shares Dated 15 September 2017 Between (each referred to as a Party and collectively as the Parties). Recitals
Shin Nippon Biomedical Laboratories, Ltd. • April 26th, 2018 • Pharmaceutical preparations

A Wave Life Sciences Ltd. (Registration No. 201218209G) (WAVE) is a company incorporated under the laws of Singapore and having its registered office at 8 Cross Street, #10-00, PWC Building, Singapore 048424.

JOINT FILING AGREEMENT
Joint Filing Agreement • March 31st, 2021 • Shin Nippon Biomedical Laboratories, Ltd. • Pharmaceutical preparations

JOINT FILING AGREEMENT dated as of March 29, 2021, by and among Shin Nippon Biomedical Laboratories, Ltd., SNBL U.S.A., Ltd. and Ken Takanashi (collectively, the “Joint Filers”).

JOINT FILING AGREEMENT
Joint Filing Agreement • April 17th, 2023 • Shin Nippon Biomedical Laboratories, Ltd. • Pharmaceutical preparations

JOINT FILING AGREEMENT dated as of April 16, 2023, by and among Shin Nippon Biomedical Laboratories, Ltd., SNBL U.S.A., Ltd., SNBL23 Merger Sub, Inc. and Ken Takanashi (collectively, the “Joint Filers”).

JOINT FILING AGREEMENT
Joint Filing Agreement • November 25th, 2015 • Shin Nippon Biomedical Laboratories, Ltd. • Pharmaceutical preparations

This Joint Filing Agreement, dated as of November 25, 2015, is by and among Shin Nippon Biomedical Laboratories, Ltd., SNBL USA, Ltd. and Ken Takanashi (collectively, the “Filers”).

SECOND AMENDMENT TO PLEDGE AGREEMENT
Pledge Agreement • April 26th, 2018 • Shin Nippon Biomedical Laboratories, Ltd. • Pharmaceutical preparations • Washington

THIS SECOND AMENDMENT TO PLEDGE AGREEMENT is dated as of December 27, 2017 (this “Amendment”) and is made by and between SNBL U.S.A. Ltd., a Washington corporation (“SNBL USA”) and The Kagoshima Bank, Ltd. (“Lender”).

Form of Lock-up Agreement
Up Agreement • November 25th, 2015 • Shin Nippon Biomedical Laboratories, Ltd. • Pharmaceutical preparations • New York
AMENDMENT TO PLEDGE AGREEMENT
Pledge Agreement • April 26th, 2018 • Shin Nippon Biomedical Laboratories, Ltd. • Pharmaceutical preparations • Washington

THIS AMENDMENT TO PLEDGE AGREEMENT is dated as of June 30, 2017 (this “Amendment”) and is made by and between SNBL U.S.A. Ltd., a Washington corporation (“SNBL USA”) and The Kagoshima Bank, Ltd. (“Lender”).

AMENDMENT TO PLEDGE AGREEMENT
Pledge Agreement • September 29th, 2016 • Shin Nippon Biomedical Laboratories, Ltd. • Pharmaceutical preparations • Washington

THIS AMENDMENT TO PLEDGE AGREEMENT is dated as of August 30, 2016 (this “Amendment”) and is made by and between SNBL U.S.A. Ltd., a Washington corporation (“SNBL USA”), and The Kagoshima Bank, Ltd. (“Lender”).

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