Tamir Biotechnology, Inc. Sample Contracts

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As of December 15, 1997
Alfacell Corp • March 17th, 1998 • Biological products, (no disgnostic substances) • Texas
ARTICLE I. DEFINITIONS
Securities Purchase Agreement • October 29th, 2003 • Alfacell Corp • Biological products, (no disgnostic substances) • New York
ARTICLE I. DEFINITIONS
Securities Purchase Agreement • July 20th, 2006 • Alfacell Corp • Biological products, (no disgnostic substances) • New York
BACKGROUND
Separation Agreement and General Release • October 14th, 2005 • Alfacell Corp • Biological products, (no disgnostic substances) • New Jersey
No. W - 1 Warrant to Purchase 10,000 Shares of Common Stock (subject to adjustment)
Warrant • December 1st, 1995 • Alfacell Corp • Biological products, (no disgnostic substances) • New Jersey
NOTE PAYABLE
Alfacell Corp • October 29th, 2003 • Biological products, (no disgnostic substances) • Delaware
AMENDED AND RESTATED TERM NOTE
Alfacell Corp • December 1st, 1995 • Biological products, (no disgnostic substances)
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LICENSE AGREEMENT
License Agreement • March 7th, 2008 • Alfacell Corp • Biological products, (no disgnostic substances) • New York

This License Agreement (the “Agreement”) is made and entered into as of January 14, 2008 (the “Effective Date”), between Alfacell Corporation, a Delaware corporation with its principal place of business at 300 Atrium Drive, Somerset, New Jersey 08873 (“Alfacell”), and Par Pharmaceutical, Inc., a Delaware corporation with its principal place of business at 300 Tice Boulevard, Woodcliff Lake, New Jersey 07677 (“Par”). Alfacell and Par may be referred to herein individually as a “Party”, or together as the “Parties”.

Contract
Form of Securities Purchase Agreement • October 15th, 2007 • Alfacell Corp • Biological products, (no disgnostic substances) • New York

FORM OF SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of July 25, 2007, between Alfacell Corporation, a Delaware corporation (the “Company”), and Unilab LP, a limited partnership organized under the laws of Maryland (the “Purchaser”). WHEREAS, subject to the terms and conditions set forth in this Agreement and pursuant to Section 4(2) of the Securities Act (as defined below) and Rule 506 promulgated thereunder, the Company desires to issue and sell to the Purchaser, and the Purchaser desires to purchase from the Company shares of common stock of the Company, as more fully described in this Agreement. NOW, THEREFORE, IN CONSIDERATION of the mutual covenants contained in this Agreement, and for other good and valuable consideration the receipt and adequacy of which are hereby acknowledged, the Company and the Purchaser agree as follows: ARTICLE I. DEFINITIONS 1.1 Definitions. In addition to the terms defined elsewhere in this Agreement, f

Contract
Distribution and Marketing Agreement • October 15th, 2007 • Alfacell Corp • Biological products, (no disgnostic substances)

DISTRIBUTION AND MARKETING AGREEMENT This Distribution and Marketing Agreement (the “Agreement”) is effective as of July 25, 2007 (“Effective Date”) and is by and between Alfacell Corporation, a Delaware corporation with principal offices at 300 Atrium Drive, Somerset, New Jersey 08873 (“Alfacell”) and USP Pharma Spolka Z.O.O., a corporation formed under the laws of Poland with principal offices at c/o US Pharmacia International, Inc., 966 Hungerford Drive, Suite 3B, Rockville, Maryland 20850 (“Distributor”). Alfacell and Distributor are referred to herein each as a “Party” and collectively as the “Parties”). WITNESSETH : WHEREAS, Alfacell is developing ONCONASE® for oncological uses and WHEREAS, Alfacell desires to appoint Distributor as the exclusive distributor in the Territory of Product for use in the Field and Distributor desires to accept such appointment, all on and subject to the terms and conditions hereinafter set forth. NOW, THEREFORE, subject to the terms and conditions of

SECOND AMENDMENT TO INVESTOR RIGHTS AGREEMENT July 31, 2010
Investor Rights Agreement • October 29th, 2010 • Tamir Biotechnology, Inc. • Biological products, (no disgnostic substances) • New York

This Second Amendment (this “Amendment”) to that certain Investor Rights Agreement dated as of October 19, 2009, as amended on February 26, 2010 (the “Agreement”), by and among Tamir Biotechnology, a Delaware corporation (f/k/a/ Alfacell Corporation) (the “Company”), and the Purchasers is made as of July 31,, 2010. Capitalized terms used but not defined herein shall have the meanings ascribed to them in the Agreement.

RETIREMENT AGREEMENT
Retirement Agreement • April 28th, 2008 • Alfacell Corp • Biological products, (no disgnostic substances) • New Jersey

This Retirement Agreement (“Agreement”) is entered into as of April 25, 2008 by Kuslima Shogen (“Employee”) and Alfacell Corporation (“Alfacell” or the “Company”).

ALFACELL CORPORATION AMENDMENT TO SECURITIES PURCHASE AGREEMENT February 26, 2010
Securities Purchase Agreement • March 4th, 2010 • Alfacell Corp • Biological products, (no disgnostic substances) • New York

This Amendment (this “Amendment”) to that certain Securities Purchase Agreement dated as of October 19, 2009 (the “Agreement”) by and among Alfacell Corporation, a Delaware corporation (the “Company”) and the investors identified on the signature pages thereto (the “Purchasers”). Capitalized terms used but not defined herein shall have the meanings ascribed to them in the Agreement.

SECURITY AGREEMENT
Security Agreement • October 20th, 2009 • Alfacell Corp • Biological products, (no disgnostic substances) • New York

THIS SECURITY AGREEMENT (this “Agreement”) is made and entered into as of October 19, 2009 by Alfacell Corporation, a Delaware corporation (the “Borrower”), and in favor of James McCash (the “Agent”) and each of the lenders whose names appear on the signature pages hereof. Such lenders are each referred to herein as a “Secured Party” and, collectively, as the “Secured Parties”. This Agreement is being executed and delivered by the Borrower and the Secured Parties in connection with that certain Securities Purchase Agreement dated concurrently herewith (the “Purchase Agreement”) by and between the Borrower and each Secured Party. Capitalized terms used herein and not otherwise defined herein shall have the respective meanings set forth in the Purchase Agreement.

ALFACELL CORPORATION SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • October 20th, 2009 • Alfacell Corp • Biological products, (no disgnostic substances) • New York

This Securities Purchase Agreement (this “Agreement”) is made and entered into as of October 19, 2009, by and among Alfacell Corporation, a Delaware corporation (the “Company”), and the investors identified on the signature pages hereto (each, a “Purchaser”, and collectively, the “Purchasers”).

Memorandum of Understanding on Co-operation between Tamir Biotechnology Inc and US Pharmacia International, Inc.
Tamir Biotechnology, Inc. • January 13th, 2012 • Biological products, (no disgnostic substances) • New Jersey

This MOU is an expression of the Parties' intention to negotiate a definitive License Agreement in accordance with the terms contained herein and with the exception of the Confidentiality Provisions this MOU is not a binding agreement. It is the intention of the parties to enter into good faith negotiations and consummate a License Agreement in the Field, in the Territory as will be described for topical formulation of Tamir’s proprietary drug Onconase/Ranprinase for treatment of patients diagnosed with Human Papillioma Virus (HPV). The terms of the MOU lay down the foundation for a definitive License Agreement that the parties shall negotiate and sign within sixty (60) days. Tamir will manufacture under GMP conditions, topical formulation of Onconase which will be used to treat genital and skin warts caused by the HPV. US Pharmacia International Inc. or any of its affiliates (USPI) shall have the exclusive rights to sell and market the product in the Field, in the Territory.

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