Ostex International Inc /Wa/ Sample Contracts

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RESEARCH AGREEMENT
Research Agreement • October 17th, 1997 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Washington
RECITALS
Development and Distribution Agreement • August 14th, 1998 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Washington
SECOND AMENDED AND RESTATED LOAN AGREEMENT
Loan Agreement • February 20th, 2003 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Massachusetts

Reference is hereby made to that certain Amended and Restated Loan Agreement (the “Prior Loan Agreement”), dated as of October 10, 2002, by and among Ostex International, Inc., a Washington corporation (the “Borrower”), and Inverness Medical Innovations, Inc., a Delaware corporation (the “Lender”). This SECOND AMENDED AND RESTATED LOAN AGREEMENT (this “Loan Agreement”) dated as of February 18, 2003, is entered into by and among the Borrower and the Lender to amend and restate the Prior Loan Agreement in its entirety. Capitalized terms used herein without definition shall have the meanings ascribed to such terms in the Merger Agreement (as defined herein).

RECITALS
Joint Development, License and Supply Agreement • October 17th, 1997 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Washington
STOCK OPTION AGREEMENT
Stock Option Agreement • September 10th, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Washington

STOCK OPTION AGREEMENT, dated as of September 6, 2002 (this "Agreement"), is made by and between Ostex International, Inc., a Washington corporation (the "Company"), and Inverness Medical Innovations, Inc., a Delaware corporation ("Parent").

AGREEMENT AND PLAN OF MERGER AMONG INVERNESS MEDICAL INNOVATIONS, INC. GERAS ACQUISITION CORP. AND OSTEX INTERNATIONAL, INC. Dated as of September 6, 2002
Merger Agreement • September 10th, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Washington

AGREEMENT AND PLAN OF MERGER (the "Agreement"), dated as of September 6, 2002, by and among Inverness Medical Innovations, Inc., a Delaware corporation ("Parent"), Geras Acquisition Corp., a Washington corporation and a wholly owned subsidiary of Parent ("MergerCo"), and Ostex International, Inc., a Washington corporation (the "Company"). Certain capitalized terms used in this Agreement are defined in Section 9.9 hereof.

VOTING AGREEMENT
Voting Agreement • September 10th, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Washington

This Voting Agreement (the "Agreement") is made and entered into as of September 6, 2002, by and between Inverness Medical Innovations, Inc., a Delaware corporation ("Parent"), Ostex International, Inc., a Washington corporation (the "Company") and the undersigned shareholders (each a "Shareholder" and collectively, the "Shareholders") of the Company. Capitalized terms used and not defined herein shall have the respective meanings ascribed to them in the Merger Agreement (as defined below).RECITALS

FIRST AMENDMENT TO RIGHTS AGREEMENT
Rights Agreement • September 19th, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Washington

This FIRST AMENDMENT TO RIGHTS AGREEMENT dated as of September 5, 2002 (the "Amendment") is entered into by and between Ostex International, Inc., a Washington corporation (the "Company"), and Mellon Investor Services LLC (the "Rights Agent").

SECOND AMENDMENT TO RIGHTS AGREEMENT
Rights Agreement • February 21st, 2003 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Washington

This SECOND AMENDMENT TO RIGHTS AGREEMENT dated as of February 18, 2003 (the "Second Amendment") is entered into by and between Ostex International, Inc., a Washington corporation (the "Company"), and Mellon Investor Services LLC (the "Rights Agent").

AMENDMENT TO AGREEMENT AND PLAN OF MERGER
Agreement and Plan of Merger • February 20th, 2003 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances
AMENDMENT AGREEMENT
Amendment Agreement • November 15th, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances

This Amendment Agreement between Ostex International, Inc. (the “Company”), a Washington corporation, and Thomas A. Bologna (“Executive”) is dated and entered into as of February 10, 1998.

Contact:
Merger Agreement • February 20th, 2003 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances
AMENDMENT TO EXCLUSIVE LICENSE AGREEMENT BETWEEN THE WASHINGTON RESEARCH FOUNDATION AND OSTEX INTERNATIONAL, INC.
Exclusive License Agreement • November 15th, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances

This Amendment is made as of September 5, 2002 (the “Effective Date”), by and between the Washington Research Foundation, a not-for-profit Washington corporation (“WRF”), and Ostex International, Inc., a Washington corporation (“Ostex”). This Amendment amends the Exclusive License Agreement by and between the WRF and Ostex made on February 10, 1994 (“Agreement”).

SECOND AMENDMENT TO OSTEOMARK-registered trademark- LICENSE AGREEMENT
Osteomark License Agreement • April 1st, 1998 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances
SERUM OSTEOMARK LICENSE AGREEMENT
License Agreement • May 1st, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances

This License Agreement (“Agreement”) is made and entered into as of February 20, 2002 (“Effective Date”), by and between Ostex International, Inc., a Washington corporation (“Ostex”) and Mochida Pharmaceutical Co., Ltd., a Japanese corporation (“Mochida”).

AMENDMENT NO. 2 TO EMPLOYMENT AGREEMENT
Employment Agreement • November 15th, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances

This Amendment No. 2 between Ostex International, Inc. (the “Company”), a Washington corporation, and Thomas A. Bologna (“Executive”) is dated and entered into as of January 16, 2002.

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RECITALS
Joint Development, License and Co-Marketing Agreement • November 14th, 1997 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Washington
MASTER LOAN AND SECURITY AGREEMENT
Master Loan and Security Agreement • March 22nd, 2001 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Illinois

THIS AGREEMENT dated as of October 23, 2000, is made by Ostex International, Inc. (the "Borrower"), a Washington corporation having its principal place of business and chief executive office at 2203 Airport Way South, Suite 400, Seattle, WA 98134, in favor of Transamerica Business Credit Corporation, a Delaware corporation (the "Lender"), having its principal office at Riverway II, West Office Tower, 9399 West Higgins Road, Rosemont, Illinois 60018.

February 18, 2003 Inverness Medical Innovations, Inc. 51 Sawyer Road Suite 200 Waltham, MA 02453-3448 Re: Letter Amendment to Voting Agreement Ladies and Gentlemen: We refer to the Voting Agreement dated as of September 6, 2002 ( the “Voting...
Voting Agreement • February 20th, 2003 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Washington

The Voting Agreement was entered into in conjunction with the Agreement and Plan of Merger, dated as of September 6, 2002 (the “Merger Agreement”), by and among Parent, Geras Acquisition Corp., a wholly owned subsidiary of Parent (“MergerCo”), and the Company (each a “Party” and collectively, the “Parties”). The Merger Agreement provides that either Parent or the Company may terminate the Merger Agreement if Parent has not, on or before November 15, 2002, received the necessary consent of its lenders to consummate the merger. In connection with Parent’s continuing efforts to obtain such consent, the Parties are simultaneously with the execution of this Letter Agreement entering into an Amendment to the Agreement and Plan of Merger, dated as of February 18, 2003 (the “Amendment”) by which the Company has agreed to a reduction of the consideration payable by Parent under the Merger Agreement.

AMENDMENT NO. 3 TO EMPLOYMENT AGREEMENT
Employment Agreement • November 15th, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances

This Amendment No. 3 between Ostex International, Inc. (the “Company”), a Washington corporation, and Thomas A. Bologna (“Executive”) is dated and entered into as of July 9, 2002.

MANUFACTURING AND LICENSE AGREEMENT
Manufacturing and License Agreement • August 14th, 2000 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Washington
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