LETTER AGREEMENT

Exhibit (g)(22)

LETTER AGREEMENT

July 22, 2010

Mr. Xxxxxxx Xxxxx
State Street Bank and Trust Company
Global Investor Services Group
0 Xxxxxx xx Xxxxxxxxx XXX0X
Xxxxxx, Xxxxxxxxxxxxx 00000

Dear Xx. Xxxxx:

This letter is to notify you that on June 24, 2010 the Trustees of Janus Investment Fund (the “Trust”) approved the name changes of the following funds effective August 2, 2010:

Current Name		New Name
Janus Smart Portfolio-Growth		Janus Growth Allocation Fund
Janus Smart Portfolio-Moderate		Janus Moderate Allocation Fund
Janus Smart Portfolio-Conservative		Janus Conservative Allocation Fund

The Trust requests confirmation that all references to “Janus Smart Portfolio-Growth, Janus Smart Portfolio-Moderate and Janus Smart Portfolio-Conservative” (the “Funds”) in the Amended and Restated Custodian Contract dated August 1, 2005, as amended, between the Trust and State Street Bank and Trust Company (“State Street”) (the “Custodian Contract”) be replaced with the corresponding new names listed above and that State Street will continue to act as custodian for the Funds under the terms of the Custodian Contract.

Please indicate your acceptance of the foregoing by executing two copies of this letter, returning one copy to the Trust and retaining one copy for your records.

JANUS INVESTMENT FUND

By:		/s/ Xxxxxxxxx Xxxxxxxxxx-Xxxxxx
		Xxxxxxxxx Xxxxxxxxxx-Xxxxxx
		Vice President and Secretary

STATE STREET BANK AND TRUST COMPANY

By:		/s/ Xxxxxxx X. Xxxxxx
		Xxxxxxx X. Xxxxxx
		Executive Vice President

Agreed to this 2nd day of August, 2010.