CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT HORIZON THERAPEUTICS PLC TREATS AS PRIVATE OR CONFIDENTIAL Amendment No. 10 to the License...

Exhibit 10.1

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT HORIZON THERAPEUTICS PLC TREATS AS PRIVATE OR CONFIDENTIAL

Amendment No. 10 to the License Agreement

This Amendment No. 10 to the License Agreement (“Amendment”) is entered into as of the 22^nd day of May 2023 (“Amendment Effective Date”) by and among

X. Xxxxxxxx-Xx Xxxxx Ltd, a corporation organized and existing under the laws of Switzerland, with its principal office at Xxxxxxxxxxxxxxxxx 000, XX-0000 Xxxxx, Xxxxxxxxxxx (“Roche Basel”) and Xxxxxxxx-Xx Xxxxx Inc., a corporation organized and existing under the laws of the State of New Jersey, with its principal office and place of business at 000 Xxxxx Xxxx, Xxxxx 0, Xxxxxx Xxxxx, XX 00000, XXX (“Roche Little Falls”; Roche Little Falls and Roche Basel together referred to as “Roche”).

And

Horizon Therapeutics Ireland DAC, a company organized and existing under the laws of Ireland, with its principal place of business at 00 Xx. Xxxxxxx’x Xxxxx, Xxxxxx 0, X00 X0X0, Xxxxxxx (as successor in interest to River Vision Development Corp) (“Horizon”).

WHEREAS, Roche and Horizon have agreed to add [***] to the Roche Patents;

WHEREAS, Roche and Horizon wish to amend the Agreement as follows:

I. Appendix 2 of the Agreement shall be deleted and replaced in its entirety by Appendix 2 attached to this Amendment.

II. Capitalized terms used herein shall have the same meaning as defined in the Agreement.

III. Except as previously stated herein, no other changes to the Agreement and all other terms and conditions of the Agreement remain in effect.

IV. This Amendment enters into effect retrospectively on the Effective Date.

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In witness whereof, the parties have executed this Amendment No. 10 to the Agreement as of the Amendment Effective Date.

X. Xxxxxxxx-Xx Xxxxx Ltd
By:		/s/ Xxxxxxx Xxxx				By:		/s/ Xxx Xxxxxxxxxx
Name:		Xxxxxxx Xxxx				Name:		Xxx Xxxxxxxxxx
Title:		Legal Counsel				Title:		Global Alliance & Asset Director
Date:		5/23/2023
Xxxxxxxx-Xx Xxxxx Inc.						Horizon Therapeutics Ireland DAC
By:		/s/ Xxxx Xxxxxx				By:		/s/ Xxxxxxx X. Xxxxxx
Name:		Xxxx Xxxxxx				Name:		Xxxxxxx X. Xxxxxx
Title:		Authorized Signatory				Title:		Director
Date:		5/23/2023				Date:		5/23/2023

2

Appendix 2

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