0000950170-23-039388 Sample Contracts

RECITALS:
Credit Agreement • August 8th, 2023 • Horizon Therapeutics Public LTD Co • Pharmaceutical preparations • Delaware

CREDIT AGREEMENT originally dated as of May 7, 2015 (as amended by Amendment No. 1, dated as of October 25, 2016, as further amended by Amendment No. 2, dated as of March 29, 2017, as further amended by Amendment No. 3, dated as of October 23, 2017, as further amended by Amendment No. 4, dated as of October 19, 2018, and as further amended by Amendment No. 5, dated as of March 11, 2019, as further amended by Amendment No. 6, dated as of May 22, 2019, as further amended by Amendment No. 7, dated as of December 18, 2019 and, as further amended by Amendment No. 8, dated as of August 17, 2020, as further amended by Amendment No. 9, dated as of March 15, 2021, and as further amended by Amendment No. 10, dated as of June 16, 2023, this “Agreement”), among HORIZON THERAPEUTICS USA, INC. (f/k/a Horizon Pharma USA, Inc.), a Delaware corporation (“HPUI”), HORIZON THERAPEUTICS PLC, an Irish public limited company (f/k/a Horizon Pharma Public Limited Company) (“Irish Holdco”), the Subsidiary Guara

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CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT HORIZON THERAPEUTICS PLC TREATS AS PRIVATE OR CONFIDENTIAL Amendment No. 10 to the License...
License Agreement • August 8th, 2023 • Horizon Therapeutics Public LTD Co • Pharmaceutical preparations

This Amendment No. 10 to the License Agreement (“Amendment”) is entered into as of the 22nd day of May 2023 (“Amendment Effective Date”) by and among

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