AGREEMENT REGARDING JOINT FILING
QuickLinks -- Click here to rapidly navigate through this document
EXHIBIT 1
AGREEMENT REGARDING JOINT FILING
The undersigned, Biotechnology Value Fund, L.P., a Delaware limited partnership, Biotechnology Value Fund II, L.P., a Delaware limited partnership, BVF Investments, L.L.C., a Delaware limited liability company, BVF Partners L.P., a Delaware limited partnership, and BVF Inc., a Delaware corporation, hereby agree and acknowledge that the information required by the Amendment to Schedule 13G, to which this Agreement is attached as an exhibit, is filed on behalf of each of them. The undersigned further agree that any further amendments or supplements thereto shall also be filed on behalf of each of them.
| Dated: | December 17, 2002 | |||||||
BIOTECHNOLOGY VALUE FUND, L.P. |
||||||||
By: |
BVF Partners L.P., its general partner |
|||||||
By: |
BVF Inc., its general partner |
|||||||
By: |
/s/ XXXX X. XXXXXXX |
|||||||
Xxxx X. Xxxxxxx President |
||||||||
BIOTECHNOLOGY VALUE FUND II, L.P. |
||||||||
By: |
BVF Partners L.P., its general partner |
|||||||
By: |
BVF Inc., its general partner |
|||||||
By: |
/s/ XXXX X. XXXXXXX |
|||||||
Xxxx X. Xxxxxxx President |
||||||||
BVF INVESTMENTS, L.L.C. |
||||||||
By: |
BVF Partners L.P., its manager |
|||||||
By: |
BVF Inc., its general partner |
|||||||
By: |
/s/ XXXX X. XXXXXXX |
|||||||
Xxxx X. Xxxxxxx President |
||||||||
BVF PARTNERS L.P. |
||||||||
By: |
BVF Inc., its general partner |
|||||||
By: |
/s/ XXXX X. XXXXXXX |
|||||||
Xxxx X. Xxxxxxx President |
||||||||
BVF INC. |
||||||||
By: |
/s/ XXXX X. XXXXXXX |
|||||||
Xxxx X. Xxxxxxx President |
||||||||
AGREEMENT REGARDING JOINT FILING
