Chiasma, Inc. Building C East Needham, MA 02494

Exhibit 10.1

Chiasma, Inc.

000 Xxxxxxxx Xxxxxx

Building C East

Needham, MA 02494

February 14, 2020

Xxx Xxxxxx

Re: Amendment to Executive Employment Letter

Dear Xxx:

This Amendment (the “Amendment”) to the Executive Employment Letter dated May 31, 2019 (the “Agreement”) confirms the amended terms and conditions of your employment with Chiasma, Inc. (the “Company”) effective February 14, 2020. Except as expressly amended herein, the Agreement remains in full effect. Your Employee Confidentiality, Assignment and Noncompetition Agreement with the Company dated May 31, 2019 is unaltered and unamended by this Amendment and remains in full effect.

Section 8(e) of the Agreement is hereby amended by:

1. Adding, after the phrase “the year in which the Change in Control occurs,” the words “(b-i) your accrued bonus (if any) with respect to the calendar year in which the Date of Termination occurs, subject to the Board’s assessment of applicable bonus criteria and prorated from the beginning of such year to the Date of Termination”; and

2. Adding, after the words “(a) and (b),” the words “and (b-i)”

This Amendment constitutes the complete agreement between you and the Company with respect to the subject matter herein and supersedes any prior agreements, representations or understandings (whether written, oral or implied) between you and the Company with respect to the subject matter herein.

Please acknowledge, by signing below, that you have accepted this Amendment.

Very Truly Yours,

/s/ Xxxxx Xxxxx

Xxxxx Xxxxx

Chairman of the Board of Directors

Chiasma, Inc.

I have read and accept this Amendment:
/s/ Xxx Xxxxxx				02/18/2020
Xxx Xxxxxx				Date