Dr. Ryuji Ueno, M.D., Ph.D., CEO, CSO & Chairman of the Board 4520 East West Highway, 3rd Floor Bethesda, Maryland 20814 Re: Amendment to Employment Agreement Dear Dr. Ueno:

Exhibit 10.6

November 15, 2007

PERSONAL AND CONFIDENTIAL

Xx. Xxxxx Xxxx, M.D., Ph.D., CEO, CSO & Chairman of the Board
0000 Xxxx Xxxx Xxxxxxx, 0^xx Xxxxx
Xxxxxxxx, Xxxxxxxx 00000

     Re:     Amendment to Employment Agreement

Dear Xx. Xxxx:

     This letter will reflect the agreement between you and Sucampo Pharmaceuticals, Inc. (the “Company”) upon certain amendments to the terms of the Employment Agreement between you and the Company dated June 16, 2006.

     Effective as of the first payroll period in June 2007, your Base Salary has been increased to the annual rate of $500,000. In addition, effective immediately, the terms of your Employment Agreement concerning Stock Compensation have been altered to eliminate the current restrictions on your eligibility to receive future stock or option grants by deleting any reference to the “Equity Eligibility Date.”

     Consistent with the requirements for modification set forth in Section 6.3 of the Employment Agreement, this letter will document the mutual agreement between you and the Company to amend Section 3.1(a) of your Employment Agreement to reflect this increase in Base Salary and Section 3.1(b) of your Employment Agreement to reflect this change to your Stock Compensation.

     The foregoing are the only changes to the terms of the Employment Agreement to be made at this time. Please indicate your agreement to these modifications of the Employment Agreement by countersigning the enclosed copy of this letter in the space provided below and returning the same to me for the Company’s files.

     Thank you for your cooperation.

Sincerely,
 

/s/ V. XXX XXXXXX  

V. Xxx Xxxxxx 

Chairperson, Compensation Committee Board of Directors 

Acknowledged and accepted this 26^th day of November, 2007.

/s/ XXXXX XXXX 

Xx. Xxxxx Xxxx, M.D., Ph.D.