0000950133-07-004983 Sample Contracts

Ms. Kei Tolliver, VP, Business Development & Company Operation 4520 East West Highway, 3rd Floor Bethesda, Maryland 20814 Re: Amendment to Employment Agreement Dear Ms. Tolliver:
Employment Agreement • December 14th, 2007 • Sucampo Pharmaceuticals, Inc. • Pharmaceutical preparations

This letter will reflect the agreement between you and Sucampo Pharmaceuticals, Inc. (the “Company”) upon certain amendments to the terms of the Employment Agreement between you and the Company dated June 16, 2006.

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Ms. Mariam Morris, Chief Accounting Officer 4520 East West Highway, 3rd Floor Bethesda, Maryland 20814 Re: Amendment to Employment Agreement Dear Mariam:
Employment Agreement • December 14th, 2007 • Sucampo Pharmaceuticals, Inc. • Pharmaceutical preparations

This letter will reflect the agreement between you and Sucampo Pharmaceuticals, Inc. (the “Company”) upon certain amendments to the terms of the Amended Employment Agreement between you and the Company dated May 12, 2007.

Mr. Brad Fackler, Executive VP, Commercial Operations 4520 East West Highway, 3rd Floor Bethesda, Maryland 20814 Re: Amendment to Employment Agreement Dear Mr. Fackler:
Employment Agreement • December 14th, 2007 • Sucampo Pharmaceuticals, Inc. • Pharmaceutical preparations

This letter will reflect the agreement between you and Sucampo Pharmaceuticals, Inc. (the “Company”) upon certain amendments to the terms of the Employment Agreement between you and the Company dated June 16, 2006.

Dr. Ryuji Ueno, M.D., Ph.D., CEO, CSO & Chairman of the Board 4520 East West Highway, 3rd Floor Bethesda, Maryland 20814 Re: Amendment to Employment Agreement Dear Dr. Ueno:
Employment Agreement • December 14th, 2007 • Sucampo Pharmaceuticals, Inc. • Pharmaceutical preparations

This letter will reflect the agreement between you and Sucampo Pharmaceuticals, Inc. (the “Company”) upon certain amendments to the terms of the Employment Agreement between you and the Company dated June 16, 2006.

Ms. Mariam Morris, Chief Accounting Officer 4520 East West Highway, 3rd Floor Bethesda, Maryland 20814 Re: Amendment to Employment Agreement Dear Mariam:
Employment Agreement • December 14th, 2007 • Sucampo Pharmaceuticals, Inc. • Pharmaceutical preparations

This letter will reflect the agreement between you and Sucampo Pharmaceuticals, Inc. (the “Company”) upon certain amendments to the terms of the Employment Agreement between you and the Company dated May 12, 2007.

Dr. Gayle R. Dolecek, Ph.D., Sr. VP, R&D 4520 East West Highway, 3rd Floor Bethesda, Maryland 20814 Re: Amendment to Employment Agreement Dear Dr. Dolecek:
Employment Agreement • December 14th, 2007 • Sucampo Pharmaceuticals, Inc. • Pharmaceutical preparations

This letter will reflect the agreement between you and Sucampo Pharmaceuticals, Inc. (the “Company”) upon certain amendments to the terms of the Employment Agreement between you and the Company dated June 16, 2006.

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