EXHIBIT A JOINT FILING AGREEMENT

EXHIBIT A

JOINT FILING AGREEMENT

The undersigned hereby agree that a single Schedule 13D (or any amendment thereto) relating to the Common Stock of Skye Bioscience, Inc. shall be filed on behalf of each of the undersigned and that this Agreement shall be filed as an exhibit to such Schedule 13D.

Dated: August 28, 2023

5AM Ventures VII, L.P.			5AM Partners VII, LLC
By:	5AM Partners VII, LLC		By:	/s/ Xxxxxx X. Xxxxxx
its	General Partner			Name: Xxxxxx X. Xxxxxx
				Title: Managing Member
By:	/s/ Xxxxxx X. Xxxxxx
	Name: Xxxxxx X. Xxxxxx
	Title: Managing Member
5AM Ventures II, L.P.			5AM Partners II, LLC
By:	5AM Partners II, LLC		By:	/s/ Xxxxxx X. Xxxxxx
its	General Partner			Name: Xxxxxx X. Xxxxxx
				Title: Managing Member
By:	/s/ Xxxxxx X. Xxxxxx
	Name: Xxxxxx X. Xxxxxx
	Title: Managing Member
5AM Co-Investors II, L.P.
By:	5AM Partners II, LLC
its	General Partner
By:	/s/ Xxxxxx X. Xxxxxx
	Name: Xxxxxx X. Xxxxxx
	Title: Managing Member
/s/ Xxxxxx X. Xxxxxx
Xxxxxx X. Xxxxxx
/s/ Xx. Xxxx Xxxxxx
Xx. Xxxx Xxxxxx
/s/ Xx. Xxxx X. Xxxxxxx
Xx. Xxxx X. Xxxxxxx
/s/ Xx. Xxxxx X. Xxxxxxxx
Xx. Xxxxx X. Xxxxxxxx