SECOND AMENDED AND RESTATED JOINT FILING AGREEMENT

EXHIBIT 16

SECOND AMENDED AND RESTATED JOINT FILING AGREEMENT

This Second Amended and Restated Joint Filing Agreement (this “Agreement”) amends and restates the Amended and Restated Joint Filing Agreement, dated March 19, 2012, by and among Invus, L.P., Invus Public Equities, L.P., Invus Advisors, L.L.C., Invus Public Equities Advisors, LLC, Xxxx, L.L.C. and Xxxxxxx Xxxxxxx.

We, the signatories of this statement on Schedule 13D to which this Agreement is attached, hereby agree that such statement is, and any amendments thereto filed by any of us will be, filed on behalf of each of us and on behalf of any affiliate of Invus, L.P. that executes a joinder hereto.

INVUS, L.P. By: INVUS ADVISORS, L.L.C., its general partner
By:		/s/ Xxxxxxx Xxxxxxx
Name:		Xxxxxxx Xxxxxxx
Title:		President

INVUS PUBLIC EQUITIES, L.P. By: INVUS PUBLIC EQUITIES ADVISORS, LLC, its general partner
By:		/s/ Xxxxxxx Xxxxxxx
Name:		Xxxxxxx Xxxxxxx
Title:		President

INVUS ADVISORS, L.L.C.
By:		/s/ Xxxxxxx Xxxxxxx
Name:		Xxxxxxx Xxxxxxx
Title:		President

INVUS PUBLIC EQUITIES ADVISORS, LLC
By:		/s/ Xxxxxxx Xxxxxxx
Name:		Xxxxxxx Xxxxxxx
Title:		President

INVUS C.V.
By: XXXX, L.L.C., its general partner
By:		/s/ Xxxxxxx Xxxxxxx
Name:		Xxxxxxx Xxxxxxx
Title:		President
XXXX, L.L.C.
By:		/s/ Xxxxxxx Xxxxxxx
Name:		Xxxxxxx Xxxxxxx
Title:		President
XXXXXXX XXXXXXX
/s/ Xxxxxxx Xxxxxxx
ARTAL INTERNATIONAL S.C.A.
By: ARTAL INTERNATIONAL MANAGEMENT S.A., its managing partner
By:		/s/ Xxxx Xxxxxxx
Name:		Xxxx Xxxxxxx
Title:		Managing Director
ARTAL INTERNATIONAL MANAGEMENT S.A.
By:		/s/ Xxxx Xxxxxxx
Name:		Xxxx Xxxxxxx
Title:		Managing Director
ARTAL GROUP S.A.
By:		/s/ Xxxx Xxxxxxx
Name:		Xxxx Xxxxxxx
Title:		Authorized Person
WESTEND S.A.
By:		/s/ Xxxxxx Xxxxx
Name:		Xxxxxx Xxxxx
Title:		Director

STICHTING ADMINISTRATIEKANTOOR WESTEND
By:		/s/ Xxxxxx Xxxxx
Name:		Xxxxxx Xxxxx
Title:		Sole Member of the Board
XX. XXXXXX XXXXX
/s/ Xxxxxx Xxxxx
Dated: April 10, 2012