Invus, L.P. Sample Contracts

LOCK-UP AGREEMENT
Lock-Up Agreement • June 6th, 2023 • Invus, L.P. • Pharmaceutical preparations
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PURCHASE AGREEMENT
Purchase Agreement • November 26th, 2014 • Invus, L.P. • Pharmaceutical preparations
THIRD AMENDED AND RESTATED JOINT FILING AGREEMENT
Joint Filing Agreement • December 16th, 2020 • Invus, L.P. • Pharmaceutical preparations

This Third Amended and Restated Joint Filing Agreement (this “Agreement”) amends and restates the Amended and Restated Joint Filing Agreement, dated April 10, 2012, by and among Invus, L.P., Invus Advisors, L.L.C., Invus Public Equities, L.P., Invus Public Equities Advisors, LLC, Invus C.V., Ulys, L.L.C., Mr. Raymond Debbane, Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., Stichting Administratiekantoor Westend (the “Stichting”) and Mr. Pascal Minne.

PURCHASE AGREEMENT
Purchase Agreement • October 15th, 2009 • Invus, L.P. • Pharmaceutical preparations
FIFTH AMENDED AND RESTATED JOINT FILING AGREEMENT
Joint Filing Agreement • January 21st, 2021 • Invus, L.P. • Pharmaceutical preparations

This Fifth Amended and Restated Joint Filing Agreement (this “Agreement”) amends and restates the Fourth Amended and Restated Joint Filing Agreement, dated January 5, 2021, by and among Invus, L.P., Invus Advisors, L.L.C., Invus Public Equities, L.P., Invus Public Equities Advisors, LLC, Invus Partners, LLC, Ulys, L.L.C., Mr. Raymond Debbane, Artal Treasury Limited, Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., Stichting Administratiekantoor Westend (the “Stichting”) and Mr. Pascal Minne.

March 11, 2024 Invus, L.P. Invus Public Equities, L.P. Invus US Partners LLC c/o The Invus Group, LLC
Series a Convertible Preferred Pipe (Voting Support) Agreement • March 13th, 2024 • Invus, L.P. • Pharmaceutical preparations
FOURTH AMENDED AND RESTATED JOINT FILING AGREEMENT
Joint Filing Agreement • January 5th, 2021 • Invus, L.P. • Pharmaceutical preparations

This Fourth Amended and Restated Joint Filing Agreement (this “Agreement”) amends and restates the Third Amended and Restated Joint Filing Agreement, dated December 16, 2020, by and among Invus, L.P., Invus Advisors, L.L.C., Invus Public Equities, L.P., Invus Public Equities Advisors, LLC, Invus C.V., Ulys, L.L.C., Mr. Raymond Debbane, Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., Stichting Administratiekantoor Westend (the “Stichting”) and Mr. Pascal Minne.

AMENDED AND RESTATED JOINT FILING AGREEMENT
Joint Filing Agreement • March 19th, 2010 • Invus, L.P. • Pharmaceutical preparations

This Amended and Restated Joint Filing Agreement (this “Agreement”) amends and restates the Joint Filing Agreement, dated June 27, 2007, by and among Invus, L.P., Invus Public Equities, L.P., Invus Advisors, L.L.C., Invus Public Equities Advisers, LLC, Ulys, L.L.C. and Raymond Debbane.

SUPPLEMENT TO TRANSACTION AGREEMENTS
Supplement to Transaction Agreements • March 19th, 2010 • Invus, L.P. • Pharmaceutical preparations • New York

This Supplement to Transaction Agreements (this “Supplement”) is entered into as of March 15, 2010 by and among Invus, L.P., a Bermuda limited partnership (“Invus, L.P.”), Invus C.V., a Netherlands limited partnership (“Invus C.V.”, and, together with Invus, L.P., the “Investors”), and Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Securities Purchase Agreement (as defined below).

October 7, 2009 Invus Public Equities, L.P. c/o The Invus Group, LLC
Voting Agreement • October 8th, 2009 • Invus, L.P. • Pharmaceutical preparations • New York
SUPPLEMENT NO. 2 TO TRANSACTION AGREEMENTS
Supplement to Transaction Agreements • February 24th, 2012 • Invus, L.P. • Pharmaceutical preparations • New York

This Supplement No. 2 to Transaction Agreements (this “Supplement”) is entered into as of February 23, 2012 by and among Invus, L.P., a Bermuda limited partnership (“Invus, L.P.”), Invus C.V., a Netherlands limited partnership (“Invus C.V.”, and, together with Invus, L.P., the “Investors”), and Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Securities Purchase Agreement (as defined below).

PURCHASE AGREEMENT
Purchase Agreement • March 19th, 2010 • Invus, L.P. • Pharmaceutical preparations
AMENDMENT TO SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • October 8th, 2009 • Invus, L.P. • Pharmaceutical preparations • New York

This Amendment to Securities Purchase Agreement (this “Amendment”) is entered into as of October 7, 2009 by and between Invus, L.P., a Bermuda limited partnership (the “Investor”), and Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Securities Purchase Agreement (as defined below).

PURCHASE AGREEMENT SUPPLEMENT
Purchase Agreement Supplement • October 15th, 2009 • Invus, L.P. • Pharmaceutical preparations
SECOND AMENDED AND RESTATED JOINT FILING AGREEMENT
Joint Filing Agreement • April 10th, 2012 • Invus, L.P. • Pharmaceutical preparations

This Second Amended and Restated Joint Filing Agreement (this “Agreement”) amends and restates the Amended and Restated Joint Filing Agreement, dated March 19, 2012, by and among Invus, L.P., Invus Public Equities, L.P., Invus Advisors, L.L.C., Invus Public Equities Advisors, LLC, Ulys, L.L.C. and Raymond Debbane.

PURCHASE AGREEMENT SUPPLEMENT
Purchase Agreement Supplement • March 19th, 2010 • Invus, L.P. • Pharmaceutical preparations
SEVENTH AMENDED AND RESTATED JOINT FILING AGREEMENT
Joint Filing Agreement • December 9th, 2024 • Invus, L.P. • Pharmaceutical preparations

This Seventh Amended and Restated Joint Filing Agreement (this “Agreement”) amends and restates the Sixth Amended and Restated Joint Filing Agreement, dated July 29, 2024.

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