EXHIBIT A
AGREEMENT REGARDING JOINT FILING
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The undersigned, Biotechnology Value Fund, L.P., a Delaware limited
partnership, and BVF Partners L.P., a Delaware limited partnership, and BVF
Inc., a Delaware corporation, hereby agree and acknowledge that the information
required by the Amendment to Schedule 13G, to which this Agreement is attached
as an exhibit, is filed on behalf of each of them. The undersigned further
agree that any subsequent amendments or supplements thereto shall also be filed
on behalf of each of them.
Dated: April 24, 1998
BIOTECHNOLOGY VALUE FUND, L.P.
By: BVF Partners L.P., its general partner
By: BVF Inc., its general partner
By: /s/ Xxxx X. Xxxxxxx
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Xxxx X. Xxxxxxx
President
BVF PARTNERS L.P.
By: BVF Inc., its general partner
By: /s/ Xxxx X. Xxxxxxx
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Xxxx X. Xxxxxxx
President
BVF INC.
By: /s/ Xxxx X. Xxxxxxx
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Xxxx X. Xxxxxxx
President
