Exhibit 4.4
Warrant
Agent Agreement
This WARRANT AGENT AGREEMENT
(this “Warrant Agreement”) dated as of October 31, 2023 is by and between Avenue Therapeutics, Inc,
a Delaware corporation (the “Company”), and VStock Transfer, LLC (the “Warrant Agent”).
WHEREAS, the Company
is selling in a public offering up to (i) 3,853,400 units (the “Units”), with each Unit consisting of (x) one
(1) share of common stock, par value $0.0001 per share (“Common Stock”), (y) one (1) Series A warrant
to purchase one share of Common Stock at an exercise price of $0.3006 (each, a “Series A Warrant” and collectively,
the “Series A Warrants”) and (z) one (1) Series B warrant to purchase one share of Common Stock
at an exercise price of $0.3006 (each, a “Series B Warrant” and collectively, the “Series B Warrants”;
the Series A Warrants and the Series B Warrants, together, the “Warrants”), (ii) 12,780,000 pre-funded
units (the “Pre-funded Units”), with each Pre-funded Unit consisting of (x) one (1) Series A Warrant,
(y) one (1) Series B Warrant and (z) one (1) pre-funded warrant to purchase one (1) share of Common Stock
at an exercise price of $0.0001 per share of Common Stock (each, a “Pre-funded Warrant” and collectively, the “Pre-funded
Warrants”);
WHEREAS, the Company
has filed, with the Securities and Exchange Commission, a registration statement on Form S-1 (Registration No. 333-274562) (as
the same may be amended from time to time, the “Registration Statement”), for the registration, under the Securities
Act of 1933, as amended, of the offer and sale of the Units, Pre-funded Units, Common Stock, Warrants, Pre-funded Warrants, and Common
Stock underlying Pre-funded Warrants and Warrants, and such Registration Statement was declared effective on October 31, 2023;
WHEREAS, the Company
desires the Warrant Agent to act on behalf of the Company, and the Warrant Agent is willing to so act, in accordance with the terms set
forth in this Warrant Agreement in connection with the issuance, registration, transfer, exchange and exercise of the Warrants and the
Pre-funded Warrants;
WHEREAS, the Company
desires to provide for the provisions of the Warrants and the Pre-funded Warrants, the terms upon which they shall be issued and exercised,
and the respective rights, limitation of rights, and immunities of the Company, the Warrant Agent, and the holders of the Warrants and
the Pre-funded Warrants; and
WHEREAS, all acts and
things have been done and performed which are necessary to make the Warrants and the Pre-funded Warrants the valid, binding and legal
obligations of the Company, and to authorize the execution and delivery of this Warrant Agreement;
NOW, THEREFORE,
in consideration of the mutual agreements herein contained, the parties hereto agree as follows:
1. Appointment
of Warrant Agent. The Company hereby appoints the Warrant Agent to act as agent for the Company with respect to the Warrants and the
Pre-funded Warrants, and the Warrant Agent xxxxxx accepts such appointment and agrees to perform the same in accordance with the express
terms and conditions set forth in this Warrant Agreement (and no implied terms or conditions).
2. Warrants.
2.1. Form of
Warrants. The Series A Warrants, the Series B Warrants and the Pre-funded Warrants shall each be registered securities and
shall be evidenced by a global warrant (each, a “Global Warrant”) in the forms of Exhibit A, Exhibit B and
Exhibit C to this Warrant Agreement, which shall be deposited on behalf of the Company with a custodian for The Depository
Trust Company (“DTC”) and registered in the name of Cede & Co., a nominee of DTC. The terms of the Global
Warrants are incorporated herein by reference. If DTC subsequently ceases to make its book-entry settlement system available for the Series A
Warrants, the Series B Warrants or the Pre-funded Warrants, the Company may instruct the Warrant Agent regarding making other arrangements
for book-entry settlement. In the event that the Series A Warrants, the Series B Warrants or the Pre-funded Warrants are not
eligible for, or it is no longer necessary to have such instruments available in, book-entry form, the Company may instruct the Warrant
Agent to provide written instructions to DTC to deliver to the Warrant Agent for cancellation the applicable Global Warrant, and the Company
shall instruct the Warrant Agent to deliver to DTC separate certificates evidencing Series A Warrants, Series B Warrants or
Pre-funded Warrants (“Definitive Certificates” and, together with the Global Warrants, “Warrant
Certificates”) registered as requested through the DTC system.
2.2. Issuance
and Registration of Warrants.
2.2.1. Warrant
Register. The Warrant Agent shall maintain books (“Warrant Register”) for the registration of original issuance
and the registration of transfer of the Warrants and the Pre-funded Warrants.
2.2.2. Issuance
of Warrants. Upon the initial issuance of the Warrants and the Pre-funded Warrants, the Warrant Agent shall issue the Global Warrants
and deliver the Warrants and the Pre-funded Warrants in the DTC book-entry settlement system in accordance with written instructions delivered
to the Warrant Agent by the Company. Ownership of security entitlements in the Warrants and the Pre-funded Warrants shall be shown on,
and the transfer of such ownership shall be effected through, records maintained (i) by DTC and (ii) by institutions that have
accounts with DTC (each, a “Participant”).
2.2.3. Beneficial
Owner; Holder. Prior to due presentment for registration of transfer of any Warrant or Pre-funded Warrant, the Company and the Warrant
Agent may deem and treat the person in whose name that Warrant or Pre-funded Warrant shall be registered on the Warrant Register (the “Holder”)
as the absolute owner of such security for purposes of any exercise thereof, and for all other purposes, and neither the Company nor the
Warrant Agent shall be affected by any notice to the contrary; provided, that the rights of beneficial owners in a Warrant or Pre-funded
Warrant evidenced by a Global Warrant shall be exercised by the Holder or a Participant through the DTC system. Notwithstanding the foregoing,
nothing herein shall prevent the Company, the Warrant Agent or any agent of the Company or the Warrant Agent from giving effect to any
written certification, proxy or other authorization furnished by DTC governing the exercise of the rights of a holder of a beneficial
interest in any Warrant or Pre-funded Warrant.
2.2.4. Delivery
of Warrant Certificate. A Holder has the right to elect at any time or from time to time a Warrant Exchange (as defined below) pursuant
to a Warrant Certificate Request Notice (as defined below). Upon written notice by a Holder to the Warrant Agent for the exchange of some
or all of such Holder’s Global Warrants for a Warrant Certificate evidencing the same number of Series A Warrants, Series B
Warrants or Pre-funded Warrants, which request shall be in the form attached hereto as Exhibit D (a “Warrant
Certificate Request Notice”) and the deemed surrender upon delivery by the Holder of a number of Global Warrants
for the same number of Series A Warrants, Series B Warrants or Pre-funded Warrants evidenced by a Warrant Certificate, a “Warrant
Exchange”), the Warrant Agent shall promptly effect the Warrant Exchange and shall promptly issue and deliver to the Holder
a Warrant Certificate for such number of Series A Warrants, Series B Warrants or Pre-funded Warrants in the name set forth in
the Warrant Certificate Request Notice. Such Warrant Certificate shall be dated the date of issuance of the Warrant Certificate, shall
include the initial exercise date of the Series A Warrants, Series B Warrants or Pre-funded Warrants, shall be executed by an
authorized signatory of the Company and shall be reasonably acceptable in all respects to such Holder. In connection with a Warrant Exchange,
the Company agrees to deliver, or to direct the Warrant Agent to deliver, the Warrant Certificate to the Holder within three (3) Business
Days of the Warrant Certificate Request Notice pursuant to the delivery instructions in the Warrant Certificate Request Notice. The Company
covenants and agrees that, upon the date of delivery of the Warrant Certificate Request Notice, the Holder shall be deemed to be the holder
of the Warrant Certificate and, notwithstanding anything to the contrary set forth herein, the Warrant Certificate shall be deemed for
all purposes to contain all of the terms and conditions of the Warrants or Pre-funded Warrants evidenced by such Warrant Certificate and
the terms of this Agreement.
2.2.5. Execution.
The Warrant Certificates shall be executed on behalf of the Company by any authorized officer of the Company (an “Authorized
Officer”), which need not be the same authorized signatory for all of the Warrant Certificates, either manually or by facsimile
signature. The Warrant Certificates shall be countersigned by an authorized signatory of the Warrant Agent, which need not be the same
signatory for all of the Warrant Certificates, and no Warrant Certificate shall be valid for any purpose unless so countersigned. In case
any Authorized Officer of the Company that signed any of the Warrant Certificates ceases to be an Authorized Officer of the Company before
countersignature by the Warrant Agent and issuance and delivery by the Company, such Warrant Certificates, nevertheless, may be countersigned
by the Warrant Agent, issued and delivered with the same force and effect as though the person who signed such Warrant Certificates had
not ceased to be such officer of the Company; and any Warrant Certificate may be signed on behalf of the Company by any person who, at
the actual date of the execution of such Warrant Certificate, shall be an Authorized Officer of the Company authorized to sign such Warrant
Certificate, although at the date of the execution of this Warrant Agreement any such person was not such an Authorized Officer.
2.2.6. Registration
of Transfer. At any time at or prior to the Termination Date (as defined below), a transfer of any Series A Warrants, Series B
Warrants or Pre-funded Warrants may be registered and any Warrant Certificate or Warrant Certificates may be split up, combined or exchanged
for another Warrant Certificate or Warrant Certificates evidencing the same number of Series A Warrants, Series B Warrants or
Pre-funded Warrants as the Warrant Certificate or Warrant Certificates surrendered. Any Holder desiring to register the transfer of Series A
Warrants, Series B Warrants or Pre-funded Warrants or to split up, combine or exchange any Warrant Certificate shall make such request
in writing delivered to the Warrant Agent, and shall surrender to the Warrant Agent the Warrant Certificate or Warrant Certificates evidencing
the Series A Warrants, the Series B Warrants or the Pre-funded Warrants the transfer of which is to be registered or that is
or are to be split up, combined or exchanged and, in the case of registration of transfer, shall provide a signature guarantee. Thereupon,
the Warrant Agent shall countersign and deliver to the person entitled thereto a Warrant Certificate or Warrant Certificates, as the case
may be, as so requested; provided, however that Series A Warrants, Series B Warrants and Pre-funded
Warrants may not be combined in the same Warrant Certificate. The Company and the Warrant Agent may require payment, by the Holder requesting
a registration of transfer of Series A Warrants, Series B Warrants or Pre-funded Warrants or a split-up, combination or exchange
of a Warrant Certificate (but, for purposes of clarity, not upon the exercise of the Warrants and issuance of Warrant Shares to the Holder),
of a sum sufficient to cover any tax or governmental charge that may be imposed in connection with such registration of transfer, split-up,
combination or exchange, together with reimbursement to the Company and the Warrant Agent of all reasonable expenses incidental thereto.
2.2.7. Loss,
Theft and Mutilation of Warrant Certificates. Upon receipt by the Company and the Warrant Agent of evidence reasonably satisfactory
to them of the loss, theft, destruction or mutilation of a Warrant Certificate, and, in case of loss, theft or destruction, of indemnity
or security in customary form and amount, and reimbursement to the Company and the Warrant Agent of all reasonable expenses incidental
thereto, and upon surrender to the Warrant Agent and cancellation of the Warrant Certificate if mutilated, the Warrant Agent shall, on
behalf of the Company, countersign and deliver a new Warrant Certificate of like tenor to the Holder in lieu of the Warrant Certificate
so lost, stolen, destroyed or mutilated. The Warrant Agent may charge the Holder an administrative fee for processing the replacement
of lost Warrant Certificates. The Warrant Agent may receive compensation from the surety companies or surety agents for administrative
services provided to them.
2.2.8. Proxies.
The Holder of a Warrant or Pre-funded Warrant may grant proxies or otherwise authorize any person, including the Participants and beneficial
holders that may own interests through the Participants, to take any action that a Holder is entitled to take under this Agreement or
the Warrants or Pre-funded Warrants; provided, however, that at all times that Warrants or Pre-funded Warrants
are evidenced by a Global Warrant, exercise of those Warrants or Pre-funded Warrants shall be effected on their behalf by Participants
through DTC in accordance the procedures administered by DTC.
3. Terms
and Exercise of Warrants.
3.1. Exercise
Price. Each Warrant shall entitle the Holder, subject to the provisions of the applicable Warrant Certificate and of this Warrant
Agreement, to purchase from the Company the number of shares of Common Stock stated therein, at the price of $0.3006 per share of Common
Stock, subject to the subsequent adjustments provided in the Global Warrant. Each Pre-funded Warrant shall entitle the Holder, subject
to the provisions of the applicable Warrant Certificate and of this Warrant Agreement to purchase from the Company the number of shares
of Common Stock stated therein, at the price of $0.0001 per share of Common Stock, subject to the subsequent adjustments provided in the
Global Warrant. The term “Exercise Price” as used in this Warrant Agreement refers to the price per
share at which shares of Common Stock may be purchased at the time a Warrant or Pre-funded Warrant is exercised.
3.2. Duration
of Warrants. A Warrant may be exercised only during the period (“Exercise Period”) commencing on the date of issuance
and ending on the Termination Date. For purposes of this Warrant Agreement, the “Termination Date” of the Series A
Warrants and the Series B Warrants shall have the meaning set forth in each Global Warrant evidencing the Series A Warrants
and Series B Warrants, respectively. Each Warrant not exercised on or before the Termination Date shall become void, and all rights
thereunder and all rights in respect thereof under this Agreement shall cease at the close of business on the Termination Date. The Pre-funded
Warrants do not expire.
3.3. Exercise
of Warrants.
3.3.1. Exercise.
Subject to the provisions of each Global Warrant, a Holder (or a Participant or a designee of a Participant acting on behalf of a Holder)
may exercise Warrants or Pre-funded Warrants by delivering to the Warrant Agent, not later than 5:00 P.M., Eastern Time, on any business
day during the Exercise Period a notice of exercise of the Warrants or Pre-funded Warrants to be exercised (i) in the form attached
to the Global Warrant or (ii) via an electronic warrant exercise through the DTC system (each, an “Election to Purchase”)
and, unless the cashless exercise procedure is specified in the applicable Election to Purchase, delivery of the aggregate Exercise Price
of the Warrant Shares specified in the applicable Election to Purchase. All other requirements for the exercise of a Warrant or Pre-funded
Warrant shall be as set forth in the Warrant or Pre-funded Warrant, respectively. Notwithstanding anything herein to the contrary, the
Holder shall not be required to physically surrender a Warrant Certificate to the Warrant Agent until the Holder has purchased all of
the Warrant Shares available thereunder and the applicable Warrant Certificate has been exercised in full, in which case, the Holder shall
surrender the Warrant Certificate to the Warrant Agent for cancellation within three (3) Trading Days of the date on which the final
Election to Purchase is delivered to the Warrant Agent. Partial exercises of a Warrant Certificate resulting in purchases of a portion
of the total number of Warrant Shares available thereunder shall have the effect of lowering the outstanding number of Warrant Shares
purchasable thereunder in an amount equal to the applicable number of Warrant Shares purchased.
3.3.2. The
Warrant Agent shall, by 5:00 P.M., Eastern Time, on the Trading Day following the Exercise Date (as defined below) of any Warrant or Pre-funded
Warrant, advise the Company, the transfer agent and registrar for the Company’s Common Stock, in respect of (i) the number
of Warrant Shares indicated on the Notice of Exercise as issuable upon such exercise with respect to such exercised Warrants, (ii) the
instructions of the Holder or Participant, as the case may be, provided to the Warrant Agent with respect to the delivery of the Warrant
Shares and the number of Warrants or Pre-Funded Warrants that remain outstanding after such exercise and (iii) such other information
as the Company or such transfer agent and registrar shall reasonably request. The Company shall issue the Warrant Shares in compliance
with the terms of the Warrant or Pre-funded Warrant, as applicable.
3.3.3. Valid
Issuance. All Warrant Shares issued by the Company upon the proper exercise of a Warrant or Pre-funded Warrant in conformity with
this Warrant Agreement shall be validly issued, fully paid and non-assessable.
3.3.4. No
Fractional Exercise. Notwithstanding any provision contained in this Warrant Agreement to the contrary, no fractional shares or scrip
representing fractional shares shall be issued upon the exercise of the Warrant or Pre-funded Warrant. As to any fraction of a share which
the Holder would otherwise be entitled to purchase upon such exercise, the Company shall, at its election, either pay a cash adjustment
in respect of such final fraction in an amount equal to such fraction multiplied by the Exercise Price or round up to the next whole share.
3.3.5. No
Transfer Taxes. The Company shall not be required to pay any stamp or other tax or governmental charge required to be paid in connection
with any transfer involved in the issue of the Warrant Shares upon the exercise of Warrants or Pre-funded Warrants; and in the event that
any such transfer is involved, the Company shall not be required to issue or deliver any Warrant Shares until such tax or other charge
shall have been paid or it has been established to the Company’s satisfaction that no such tax or other charge is due.
3.3.6. Date
of Issuance. The Company will treat an exercising Holder as a beneficial owner of the Warrant Shares as of the time of delivery of
a Notice of Exercise (as defined in the Warrant Certificate) to the Warrant Agent or the Company, and for purposes of Regulation SHO,
a holder whose interest in the Warrant or Pre-funded Warrant is a beneficial interest in certificate(s) representing the Warrant
or Pre-funded Warrant held in book-entry form through DTC shall be deemed to have exercised its interest in the Warrant or Pre-funded
Warrant upon instructing its broker that is a DTC participant to exercise its interest in the Warrant or Pre-funded Warrant (the date
of any such exercise, an “Exercise Date”), except that, if the Exercise Date is a date when the stock transfer books
of the Company are closed, such person shall be deemed to have become the holder of such shares at the open of business on the next succeeding
date on which the stock transfer books are open.
4. Adjustments.
Upon every adjustment of the Exercise Price or the number of Warrant Shares issuable upon exercise of a Warrant or Pre-funded Warrant,
the Company shall give written notice thereof to the Warrant Agent, which notice shall state the Exercise Price resulting from such adjustment
and the increase or decrease, if any, in the number of Warrant Shares purchasable at such price upon the exercise of a Warrant or Pre-funded
Warrant, setting forth in reasonable detail the method of calculation and the facts upon which such calculation is based. Upon the occurrence
of any event specified in Section 3 of the Warrant or Pre-funded Warrant, then, in any such event, the Company shall give written
notice to the Warrant Agent. Failure to give such notice, or any defect therein, shall not affect the legality or validity of such event.
The Warrant Agent shall be entitled to rely conclusively on, and shall be fully protected in relying on, any certificate, notice or instructions
provided by the Company with respect to any adjustment of the Exercise Price or the number of shares issuable upon exercise of a Warrant
or Pre-funded Warrant, or any related matter, and the Warrant Agent shall not be liable for any action taken, suffered or omitted to be
taken by it in accordance with any such certificate, notice or instructions or pursuant to this Warrant Agreement. The Warrant Agent shall
not be deemed to have knowledge of any such adjustment unless and until it shall have received written notice thereof from the Company.
5. Restrictive
Legends; Fractional Warrants. In the event that a Warrant Certificate surrendered for transfer bears a restrictive legend, the Warrant
Agent shall not register that transfer until the Warrant Agent has received an opinion of counsel for the Company stating that such transfer
may be made and indicating whether the Warrants or Pre-funded Warrants must also bear a restrictive legend upon that transfer. The Warrant
Agent shall not be required to effect any registration of transfer or exchange which will result in the transfer of or delivery of a Warrant
Certificate for a fraction of a Warrant or Pre-funded Warrant.
6 . Other
Provisions Relating to Rights of Holders of Warrants.
6.1. No
Rights as Stockholder. Except as otherwise specifically provided herein, a Holder, solely in its capacity as a holder of Warrants
or Pre-funded Warrants, shall not be entitled to vote or receive dividends or be deemed the holder of share capital of the Company for
any purpose, nor shall anything contained in this Warrant Agreement be construed to confer upon a Holder, solely in its capacity as the
registered holder of Warrants or Pre-funded Warrants, any of the rights of a stockholder of the Company or any right to vote, give or
withhold consent to any corporate action (whether any reorganization, issue of stock, reclassification of share capital, consolidation,
merger, conveyance or otherwise), receive notice of meetings, receive dividends or subscription rights or rights to participate in new
issues of shares, or otherwise, prior to the issuance to the Holder of the Warrant Shares which it is then entitled to receive upon the
due exercise of Warrants or Pre-funded Warrants.
6.2. Reservation
of Common Stock. The Company shall at all times reserve and keep available a number of its authorized but unissued shares of Common
Stock that will be sufficient to permit the exercise in full of all outstanding Warrants and Pre-funded Warrants issued pursuant to this
Warrant Agreement.
7. Concerning
the Warrant Agent and Other Matters.
7.1. Any
instructions given to the Warrant Agent orally, as permitted by any provision of this Warrant Agreement, shall be confirmed in writing
by the Company as soon as practicable. The Warrant Agent shall not be liable or responsible and shall be fully authorized and protected
for acting, or failing to act, in accordance with any oral instructions which do not conform with the written confirmation received in
accordance with this Section 7.1.
7.2. (a) Whether
or not any Warrants or Pre-funded Warrants are exercised, for the Warrant Agent’s services as agent for the Company hereunder, the
Company shall pay to the Warrant Agent such fees as may be separately agreed between the Company and Warrant Agent. (b) All amounts
owed by the Company to the Warrant Agent under this Warrant Agreement are due within 30 days of the invoice date. Delinquent payments
are subject to a late payment charge of one and one-half percent (1.5%) per month commencing 45 days from the invoice date. The Company
agrees to reimburse the Warrant Agent for any attorney’s fees and any other costs associated with collecting delinquent payments.
(c) No provision of this Warrant Agreement shall require Warrant Agent to expend or risk its own funds or otherwise incur any financial
liability in the performance of any of its duties under this Warrant Agreement or in the exercise of its rights.
7.3. As
agent for the Company hereunder the Warrant Agent: (a) shall have no duties or obligations other than those specifically set forth
herein or as may subsequently be agreed to in writing by the Warrant Agent and the Company; (b) shall be regarded as making no representations
and having no responsibilities as to the validity, sufficiency, value, or genuineness of the Warrants, Pre-funded Warrants or any Warrant
Shares; (c) shall not be obligated to take any legal action hereunder; if, however, the Warrant Agent determines to take any legal
action hereunder, and where the taking of such action might, in its judgment, subject or expose it to any expense or liability it shall
not be required to act unless it has been furnished with an indemnity reasonably satisfactory to it; (d) may rely on and shall be
fully authorized and protected in acting or failing to act upon any certificate, instrument, opinion, notice, letter or other document
or security delivered to the Warrant Agent and believed by it to be genuine and to have been signed by the proper party or parties; (e) shall
not be liable or responsible for any recital or statement contained in the Registration Statement or any other documents relating thereto;
(f) shall not be liable or responsible for any failure on the part of the Company to comply with any of its covenants and obligations
relating to the Warrants and Pre-funded Warrants, including without limitation obligations under applicable securities laws; (g) may
rely on and shall be fully authorized and protected in acting or failing to act upon the written, telephonic or oral instructions with
respect to any matter relating to its duties as Warrant Agent covered by this Warrant Agreement (or supplementing or qualifying any such
actions) of officers of the Company, and is hereby authorized and directed to accept instructions with respect to the performance of its
duties hereunder from the Company or counsel to the Company, and may apply to the Company, for advice or instructions in connection with
the Warrant Agent’s duties hereunder, and the Warrant Agent shall not be liable for any delay in acting while waiting for those
instructions; any applications by the Warrant Agent for written instructions from the Company may, at the option of the Warrant Agent,
set forth in writing any action proposed to be taken or omitted by the Warrant Agent under this Warrant Agreement and the date on or after
which such action shall be taken or such omission shall be effective; the Warrant Agent shall not be liable for any action taken by, or
omission of, the Warrant Agent in accordance with a proposal included in such application on or after the date specified in such application
(which date shall not be less than five business days after the date such application is sent to the Company, unless the Company shall
have consented in writing to any earlier date) unless prior to taking any such action, the Warrant Agent shall have received written instructions
in response to such application specifying the action to be taken or omitted; (h) may consult with counsel satisfactory to the Warrant
Agent, including its in-house counsel; (i) may perform any of its duties hereunder either directly or by or through nominees, correspondents,
designees, or subagents, and it shall not be liable or responsible for any misconduct or negligence on the part of any nominee, correspondent,
designee, or subagent appointed with reasonable care by it in connection with this Warrant Agreement; (j) is not authorized, and
shall have no obligation, to pay any brokers, dealers, or soliciting fees to any person; and (k) shall not be required hereunder
to comply with the laws or regulations of any country other than the United States of America or any political subdivision thereof.
7.4. (a) In
the absence of gross negligence or willful or illegal misconduct on its part, the Warrant Agent shall not be liable for any action taken,
suffered, or omitted by it or for any error of judgment made by it in the performance of its duties under this Warrant Agreement. Anything
in this Warrant Agreement to the contrary notwithstanding, in no event shall Warrant Agent be liable for special, indirect, incidental,
consequential or punitive losses or damages of any kind whatsoever (including but not limited to lost profits, liquidated damages or buy-in
claims), even if the Warrant Agent has been advised of the possibility of such losses or damages and regardless of the form of action.
Any liability of the Warrant Agent will be limited in the aggregate to the amount of fees paid by the Company hereunder. The Warrant Agent
shall not be liable for any failures, delays or losses, arising directly or indirectly out of conditions beyond its reasonable control
including, but not limited to, acts of government, exchange or market ruling, suspension of trading, work stoppages or labor disputes,
fires, civil disobedience, riots, rebellions, storms, electrical or mechanical failure, computer hardware or software failure, communications
facilities failures including telephone failure, war, terrorism, insurrection, earthquakes, floods, acts of God or similar occurrences.
(b) In the event any question or dispute arises with respect to the proper interpretation of the Warrants or the Warrant Agent’s
duties under this Warrant Agreement or the rights of the Company or of any Holder, the Warrant Agent shall not be required to act and
shall not be held liable or responsible for its refusal to act until the question or dispute has been judicially settled (and, if appropriate,
it may file a suit in interpleader or for a declaratory judgment for such purpose) by final judgment rendered by a court of competent
jurisdiction, binding on all persons interested in the matter which is no longer subject to review or appeal, or settled by a written
document in form and substance satisfactory to Warrant Agent and executed by the Company and each such Holder. In addition, the Warrant
Agent may require for such purpose, but shall not be obligated to require, the execution of such written settlement by all the Holders
and all other persons that may have an interest in the settlement.
7.5. The
Company covenants to indemnify the Warrant Agent and hold it harmless from and against any loss, liability, claim or expense (“Loss”)
arising out of or in connection with the Warrant Agent’s duties under this Warrant Agreement, including the costs and expenses of
defending itself against any Loss, unless such Loss shall have been determined by a court of competent jurisdiction to be a result of
the Warrant Agent’s gross negligence or willful or illegal misconduct.
7.6. Unless
terminated earlier by the parties hereto, this Agreement shall terminate 90 days after the later of the Termination Date (as defined in
the Warrants and Pre-funded Warrants) and the date on which no Warrants remain outstanding (the “Termination Date”).
On the business day following the Termination Date, the Warrant Agent shall deliver to the Company any entitlements, if any, held by the
Warrant Agent under this Warrant Agreement. The Agent’s right to be reimbursed for fees, charges and out-of-pocket expenses as provided
in this Section 8 shall survive the termination of this Warrant Agreement.
7.7. If
any provision of this Warrant Agreement shall be held illegal, invalid, or unenforceable by any court, this Warrant Agreement shall be
construed and enforced as if such provision had not been contained herein and shall be deemed an agreement among the parties to it to
the full extent permitted by applicable law.
7.8. The
Company represents and warrants that: (a) it is duly incorporated and validly existing under the laws of its jurisdiction of incorporation;
(b) the offer and sale of the Warrants and Pre-funded Warrants and the execution, delivery and performance of all transactions contemplated
thereby (including this Warrant Agreement) have been duly authorized by all necessary corporate action and will not result in a breach
of or constitute a default under the articles of association, bylaws or any similar document of the Company or any indenture, agreement
or instrument to which it is a party or is bound; (c) this Warrant Agreement has been duly executed and delivered by the Company
and constitutes the legal, valid, binding and enforceable obligation of the Company; (d) the Warrants and Pre-funded Warrants will
comply in all material respects with all applicable requirements of law; and (e) to the best of its knowledge, there is no litigation
pending or threatened as of the date hereof in connection with the offering of the Warrants or Pre-funded Warrants.
7.9. In
the event of inconsistency between this Warrant Agreement and the terms set forth in the Warrant Certificate with respect to a Warrant
or Pre-funded Warrant, as it may from time to time be amended, the terms of the Warrant Certificate shall control.
7.10. Set
forth in Exhibit E hereto is a list of the names and specimen signatures of the persons authorized to act for the
Company under this Warrant Agreement (the “Authorized Representatives”). The Company shall, from time to time,
certify to the Warrant Agent the names and signatures of any other persons authorized to act for the Company under this Warrant Agreement.
7.11. Except
as expressly set forth elsewhere in this Warrant Agreement, all notices, instructions and communications under this Agreement shall be
in writing, shall be effective upon receipt and shall be addressed, if to the Company, to its address set forth beneath its signature
to this Agreement, or, if to the Warrant Agent, to VStock Transfer, LLC, 00 Xxxxxxxxx Xxxxx, Xxxxxxxx, XX 00000, or to such other address
of which a party hereto has notified the other party.
7.12. (a) This
Warrant Agreement shall be governed by and construed in accordance with the laws of the State of New York. All actions and proceedings
relating to or arising from, directly or indirectly, this Warrant Agreement may be litigated in courts located within the Borough of Manhattan
in the City and State of New York. The Company hereby submits to the personal jurisdiction of such courts and consents that any service
of process may be made by certified or registered mail, return receipt requested, directed to the Company at its address last specified
for notices hereunder. (b) This Warrant Agreement shall inure to the benefit of and be binding upon the successors and assigns of
the parties hereto. This Warrant Agreement may not be assigned, or otherwise transferred, in whole or in part, by either party without
the prior written consent of the other party, which the other party will not unreasonably withhold, condition or delay; except that (i) consent
is not required for an assignment or delegation of duties by Warrant Agent to any affiliate of Warrant Agent and (ii) any reorganization,
merger, consolidation, sale of assets or other form of business combination by the Warrant Agent or the Company shall not be deemed to
constitute an assignment of this Warrant Agreement. (c) No provision of this Warrant Agreement may be amended, modified or waived,
except in a written document signed by both parties.
7.13. Payment
of Taxes. The Company will from time to time promptly pay all taxes and charges that may be imposed upon the Company or the Warrant
Agent in respect of the issuance or delivery of Warrant Shares upon the exercise of Warrants and Pre-funded Warrants, but the Company
may require the Holders to pay any transfer taxes in respect of the Warrants or such shares. The Warrant Agent may refrain from registering
any transfer of Warrants or Pre-funded Warrants or any delivery of any Warrant Shares unless or until the persons requesting the registration
or issuance shall have paid to the Warrant Agent for the account of the Company the amount of such tax or charge, if any, or shall have
established to the reasonable satisfaction of the Company and the Warrant Agent that such tax or charge, if any, has been paid.
7.14. Resignation
of Warrant Agent.
7.14.1. Appointment
of Successor Warrant Agent. The Warrant Agent, or any successor to it hereafter appointed, may resign its duties and be discharged
from all further duties and liabilities hereunder after giving thirty (30) days’ notice in writing to the Company, or such shorter
period of time agreed to by the Company. The Company may terminate the services of the Warrant Agent, or any successor Warrant Agent,
after giving thirty (30) days’ notice in writing to the Warrant Agent or successor Warrant Agent, or such shorter period of time
as agreed. If the office of the Warrant Agent becomes vacant by resignation, termination or incapacity to act or otherwise, the Company
shall appoint in writing a successor Warrant Agent in place of the Warrant Agent. If the Company shall fail to make such appointment within
a period of 30 days after it has been notified in writing of such resignation or incapacity by the Warrant Agent, then the Warrant Agent
or any Holder may apply to any court of competent jurisdiction for the appointment of a successor Warrant Agent at the Company’s
cost. Pending appointment of a successor to such Warrant Agent, either by the Company or by such a court, the duties of the Warrant Agent
shall be carried out by the Company. Any successor Warrant Agent (but not including the initial Warrant Agent), whether appointed by the
Company or by such court, shall be a person organized and existing under the laws of any state of the United States of America, in good
standing, and authorized under such laws to exercise corporate trust powers and subject to supervision or examination by federal or state
authority. After appointment, any successor Warrant Agent shall be vested with all the authority, powers, rights, immunities, duties,
and obligations of its predecessor Warrant Agent with like effect as if originally named as Warrant Agent hereunder, without any further
act or deed, and except for executing and delivering documents as provided in the sentence that follows, the predecessor Warrant Agent
shall have no further duties, obligations, responsibilities or liabilities hereunder, but shall be entitled to all rights that survive
the termination of this Warrant Agreement and the resignation or removal of the Warrant Agent, including but not limited to its right
to indemnity hereunder. If for any reason it becomes necessary or appropriate or at the request of the Company, the predecessor Warrant
Agent shall execute and deliver, at the expense of the Company, an instrument transferring to such successor Warrant Agent all the authority,
powers, and rights of such predecessor Warrant Agent hereunder; and upon request of any successor Warrant Agent the Company shall make,
execute, acknowledge, and deliver any and all instruments in writing for more fully and effectually vesting in and confirming to such
successor Warrant Agent all such authority, powers, rights, immunities, duties, and obligations.
7.14.2. Notice
of Successor Warrant Agent. In the event a successor Warrant Agent shall be appointed, the Company shall give notice thereof to the
predecessor Warrant Agent and the transfer agent for the Common Stock not later than the effective date of any such appointment.
7.14.3. Merger
or Consolidation of Warrant Agent. Any person into which the Warrant Agent may be merged or converted or with which it may be consolidated
or any person resulting from any merger, conversion or consolidation to which the Warrant Agent shall be a party or any person succeeding
to the shareowner services business of the Warrant Agent or any successor Warrant Agent shall be the successor Warrant Agent under this
Warrant Agreement, without any further act or deed. For purposes of this Warrant Agreement, “person” shall mean any individual,
firm, corporation, partnership, limited liability company, joint venture, association, trust or other entity, and shall include any successor
(by merger or otherwise) thereof or thereto.
8. Miscellaneous
Provisions.
8.1. Persons
Having Rights under this Warrant Agreement. Nothing in this Warrant Agreement expressed and nothing that may be implied from any of
the provisions hereof is intended, or shall be construed, to confer upon, or give to, any person or corporation other than the parties
hereto any right, remedy, or claim under or by reason of this Warrant Agreement or of any covenant, condition, stipulation, promise, or
agreement hereof.
8.2. Examination
of the Warrant Agreement. A copy of this Warrant Agreement shall be available at all reasonable times at the office of the Warrant
Agent designated for such purpose for inspection by any Holder. Prior to such inspection, the Warrant Agent may require any such holder
to provide reasonable evidence of its interest in the Warrants or the Pre-funded Warrants.
8.3. Counterparts.
This Warrant Agreement may be executed in any number of original, facsimile or electronic counterparts and each of such counterparts shall
for all purposes be deemed to be an original, and all such counterparts shall together constitute but one and the same instrument.
8.4. Effect
of Headings. The Section headings herein are for convenience only and are not part of this Warrant Agreement and shall not affect
the interpretation thereof.
9. Certain
Definitions. As used herein, the following terms shall have the following meanings:
| (a) | “Trading Day” means any day on which the Common Stock is traded on the Trading
Market, or, if the Trading Market is not the principal trading market for the Common Stock, then on the principal securities exchange
or securities market in the United States on which the Common Stock are then traded, provided that “Trading Day” shall
not include any day on which the Common Stock is scheduled to trade on such exchange or market for less than 4.5 hours or any day that
the Common Stock are suspended from trading during the final hour of trading on such exchange or market (or if such exchange or market
does not designate in advance the closing time of trading on such exchange or market, then during the hour ending at 4:00 P.M., Eastern
Time). |
| (b) | “Trading Market” means NYSE American, the Nasdaq Capital Market, the Nasdaq Global
Market, the Nasdaq Global Select Market or the New York Stock Exchange. |
[Signature Page Follows]
IN WITNESS WHEREOF, this Warrant
Agent Agreement has been duly executed by the parties hereto as of the day and year first above written.
|
AVENUE THERAPEUTICS, INC. |
|
|
|
|
By: |
/s/ Xxxxxxxxx XxxXxxx |
|
Name: |
Xxxxxxxxx XxxXxxx, M.D. |
|
Title: |
Chief Executive Officer |
|
Address: |
0000 Xxxx Xxxxxxxxx, Xxxxx 000 |
|
|
Bay Harbor Islands, Florida 33154 |
|
VSTOCK TRANSFER, LLC |
|
|
|
|
By: |
/s/ Xxxxx Xxxx |
|
Name: |
Xxxxx Xxxx |
|
Title: |
Compliance Officer |
[WARRANT AGREEMENT]
EXHIBIT A
GLOBAL
SERIES A WARRANT
[See
attached.]
EXHIBIT B
GLOBAL
SERIES B WARRANT
[See
attached.]
EXHIBIT C
GLOBAL
PRE-FUNDED WARRANT
[See
attached.]
EXHIBIT D
WARRANT CERTIFICATE REQUEST NOTICE
To: ___________ as Warrant Agent for __________
(the “Company”)
The undersigned Holder of Common Stock Purchase
Warrants (“Warrants”) in the form of Global Warrants issued by the Company hereby elects to receive a Warrant Certificate
evidencing the Warrants held by the Holder as specified below:
1. |
Name of Holder of Warrants in form of Global Warrants: _____________________________ |
|
|
2. |
Name of Holder in Warrant Certificate (if different from name of Holder of Warrants in form of Global Warrants): ________________________________ |
|
|
3. |
Number of Warrants in name of Holder in form of Global Warrants: ___________________ |
|
|
4. |
Number of Warrants for which Warrant Certificate shall be issued: __________________ |
|
|
5. |
Series of Warrants to which this Certificate Request Notice applies (Series A, Series B or Pre-funded): _________________ |
|
|
6. |
Number of Warrants in name of Holder in form of Global Warrants after issuance of Warrant Certificate, if any: ___________ |
|
|
7. |
Warrant Certificate shall be delivered to the following address: |
______________________________
______________________________
______________________________
______________________________
The undersigned hereby acknowledges and agrees
that, in connection with this Warrant Exchange and the issuance of the Warrant Certificate, the Holder is deemed to have surrendered the
number of Warrants in form of Global Warrants in the name of the Holder equal to the number of Warrants evidenced by the Warrant Certificate.
[SIGNATURE
OF HOLDER]
Name of Investing Entity: ____________________________________________________
Signature of Authorized Signatory of Investing
Entity: ______________________________
Name of Authorized Signatory: ________________________________________________
Title of Authorized Signatory: _________________________________________________
Date: _______________________________________________________________
EXHIBIT E
AUTHORIZED REPRESENTATIVES
Name |
|
Title |
|
Signature |
Xxxxxxxxx XxxXxxx |
|
Chief Executive Officer |
|
|
|
|
|
|
|
Xxxxx Xxx |
|
Interim Chief Financial Officer & Chief Operating Officer |
|
|