General introductionDoctoral Thesis • December 10th, 2008
Contract Type FiledDecember 10th, 2008Cells are the building blocks of life; the human body is composed of approximately 100 trillion of them. It is not an unreasonable assumption that properties of the species should be reflected in properties of their cells. Cell turnover during life history, which is essential for tissue maintenance, might be a primary mechanism of organismal ageing (Hayflick, 1985). Very recently conducted studies support a model in which ageing may results of adult stem cell dysfunction and progressive deterioration of tissue functions (Scaffidi and Misteli, 2006, 2008).
General introductionDoctoral Thesis • December 10th, 2008
Contract Type FiledDecember 10th, 2008Cells are the building blocks of life; the human body is composed of approximately 100 trillion of them. It is not an unreasonable assumption that properties of the species should be reflected in properties of their cells. Cell turnover during life history, which is essential for tissue maintenance, might be a primary mechanism of organismal ageing (Hayflick, 1985). Very recently conducted studies support a model in which ageing may results of adult stem cell dysfunction and progressive deterioration of tissue functions (Scaffidi and Misteli, 2006, 2008).