License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of LeidenDoctoral Thesis • November 13th, 2008
Contract Type FiledNovember 13th, 2008Metal complexes of active drugs have been developed in the recent years and could have important pharmacological activities, mainly because complexation with the metal can protect the drug against enzymatic degradation, can produce more convenient hydrophobicity/hydrophilicity properties, can improve transport processes and/or can give extra organ-specificity. Finally, the biological activity can be reinforced by the combination of effects from the ligands and from the metal moiety.
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of LeidenDoctoral Thesis • November 13th, 2008
Contract Type FiledNovember 13th, 2008Metal complexes of active drugs have been developed in the recent years and could have important pharmacological activities, mainly because complexation with the metal can protect the drug against enzymatic degradation, can produce more convenient hydrophobicity/hydrophilicity properties, can improve transport processes and/or can give extra organ-specificity. Finally, the biological activity can be reinforced by the combination of effects from the ligands and from the metal moiety.