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PHARMACOKINETICS AND PHARMACODYNAMICS ANALYSIS OF TRANSDERMAL IONTOPHORESIS OF 5-OH DPAT IN RATS: IN VITRO – IN VIVO CORRELATIONDoctoral Thesis • July 13th, 2023
Fig. 9. The prediction of the Cp (panel A), Cs (panel B), and CDA (panel C) following transdermal iontophoresis of 5-OH-DPAT on the basis of the optimum values of the in vitro transport parameters. The dashed lines are the range of 95% confidence interval of the population prediction of Cp, Cs, or CDA. The solid line is the geometric mean of the population prediction of Cp, Cs, or CDA. The filled circles are the observed data of Cp, Cs, and CDA following transdermal iontophoretic delivery of 5-OH-DPAT.
