Table 1. Agreement between modified Boolean indices and disease activityClinical Study Agreement • May 13th, 2023
Contract Type FiledMay 13th, 2023efficacy of split versus non-split doses of methotrexate (MTX). For this analysis, data from both groups was analyzed together. Patients are started on oral MTX 15 mg/week which was escalated every two weeks by 5 mg, to reach a maxi- mum dose of 25 mg/week by 4 weeks. At the end of 16 weeks, if Disease Activity Score 28 (DAS28) >3.2 another DMARD can be added. Disease activity was measured using the DAS28, Simplified Disease Activity Index (SDAI) and Clini-