0000875320-22-000007 Sample Contracts

RE: Change of Control Agreement Dear Nia:
Vertex Pharmaceuticals Inc / Ma • February 9th, 2022 • Pharmaceutical preparations • Massachusetts

You are a key member of the senior management team of Vertex Pharmaceuticals Incorporated (the “Company”). As a result, the Company would like to provide you with the following “change of control” benefits to help ensure that if the Company becomes involved in a “change of control” transaction, there will be no distraction from your attention to the needs of the Company.

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EMPLOYMENT AGREEMENT
Employment Agreement • February 9th, 2022 • Vertex Pharmaceuticals Inc / Ma • Pharmaceutical preparations • Massachusetts

This Employment Agreement (this “Agreement”) is made and entered into as of this 1st day of August, 2020, by and between Vertex Pharmaceuticals Incorporated, a Massachusetts corporation (together with its successors and assigns, the “Company”), and Nia Tatsis (the “Executive”).

AMENDMENT NO. 1 TO EMPLOYMENT AGREEMENT
Employment Agreement • February 9th, 2022 • Vertex Pharmaceuticals Inc / Ma • Pharmaceutical preparations

This AMENDMENT NO. 1 is made and entered into effective as of February 7, 2022 (the “Effective Date”) to the employment agreement dated as of April 1, 2020 (the “Employment Agreement”), between Vertex Pharmaceuticals Incorporated (the “Company”) and Jeffrey M. Leiden, MD., Ph.D. (the “Executive”).

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