0000886163-13-000060 Sample Contracts

June 19, 2013 Biotechnology Value Fund, L.P.
Letter Agreement • June 20th, 2013 • Ligand Pharmaceuticals Inc • Pharmaceutical preparations • Delaware
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FIRST AMENDMENT TO 2006 PREFERRED SHARES RIGHTS AGREEMENT
2006 Preferred Shares Rights Agreement • June 20th, 2013 • Ligand Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

This First Amendment to 2006 Preferred Shares Rights Agreement (this “Amendment”) dated as of June 19, 2013, is entered into by and between Ligand Pharmaceuticals Incorporated, a Delaware corporation (the “Company”) and Computershare Shareowner Services LLC (f/k/a Mellon Investor Services LLC), as Rights Agent (the “Rights Agent”). Capitalized terms used and not otherwise defined herein that are defined in this Amendment shall have the meanings given such terms in the Original Agreement (as defined below).

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