0000898430-02-004065 Sample Contracts

FIRST AMENDMENT TO THE EXECUTIVE EMPLOYMENT AGREEMENT FOR JOHN N. BONFIGLIO, PH.D.
Executive Employment Agreement • November 13th, 2002 • Cypress Bioscience Inc • Biological products, (no disgnostic substances)

This First Amendment (this “Amendment”) dated August 26, 2002 (the “Effective Date”) amends the Employment Agreement (the “Agreement”) dated June 18, 2001 (the “Effective Date”) between CYPRESS BIOSCIENCE, INC. (“Employer”) and JOHN N. BONFIGLIO, PH.D. (“Executive”).

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COMMON STOCK ISSUANCE AGREEMENT
Common Stock Issuance Agreement • November 13th, 2002 • Cypress Bioscience Inc • Biological products, (no disgnostic substances) • California

THIS AGREEMENT (this “Agreement”) is made as of October 31, 2002 (the “Effective Date”), by and between CYPRESS BIOSCIENCE, INC., a Delaware corporation having a principal place of business at 4350 Executive Drive, Suite 325, San Diego, California 92121 (“Cypress”), and COLLEGIUM PHARMACEUTICAL, INC., a Delaware corporation (“Collegium”) having a principal place of business at 349 Lincoln Street, Hingham, Massachusetts 02043.

REFORMULATION AND NEW PRODUCT AGREEMENT
Reformulation and New Product Agreement • November 13th, 2002 • Cypress Bioscience Inc • Biological products, (no disgnostic substances) • California

THIS REFORMULATION AND NEW PRODUCT AGREEMENT is made as of August 22, 2002 (the “Effective Date”), by and between CYPRESS BIOSCIENCE, INC., a Delaware corporation (“Cypress”), having a principal place of business at 4350 Executive Drive, Suite 325, San Diego, California 92121, and COLLEGIUM PHARMACEUTICAL, INC., a Delaware corporation (“Collegium”), having a principal place of business at 349 Lincoln Street, Hingham, Massachusetts, 02043. Cypress and Collegium may be referred to herein individually as a “Party” and collectively as the “Parties.”

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