0000912057-00-052268 Sample Contracts

LICENSE AGREEMENT
License Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research • Florida

This License Agreement (the "Agreement") is entered into and made effective the 20th day of September, 1999 (the "Effective Date") between UNIVERSITY OF MIAMI and its School of Medicine, whose principal place of business is at 1600 N.W. 10th Avenue, Miami, Florida 33136 (hereinafter referred to as "LICENSOR") and Seattle Genetics, Inc., whose principal place of business is at 22215 26th Avenue S.E., Suite 3000, Bothell, Washington 98021, hereinafter referred to as "LICENSEE").

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DEVELOPMENT AND LICENSE AGREEMENT GENENTECH, INC. AND SEATTLE GENETICS, INC.
Development and License Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research • Washington

This Development and License Agreement (this "Agreement") is made effective as of June 30, 1999 (the "Effective Date") by and between Genentech, Inc. ("GNE"), a Delaware corporation with its principal office at 1 DNA Way, South San Francisco, California 94080 and Seattle Genetics, Inc. ("SG"), a Delaware corporation with its principal office at 22215 26th Avenue SE, Bothell, Washington 98021, each on behalf of itself and its Affiliates. GNE and SG are sometimes referred to herein individually as a "Party" and collectively as the "Parties," and references to "GNE" and "SG" shall include their respective Affiliates.

LICENSE AGREEMENT BETWEEN BRISTOL-MYERS SQUIBB AND COMPANY SEATTLE GENETICS, INC. DATED AS OF MARCH 30, 1998
License Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research • New York

THIS LICENSE AGREEMENT (this "Agreement") dated as of March 30, 1998 by and between Bristol-Myers Squibb Company, a corporation duly organized and existing under the laws of the State of Delaware, having offices at P.O. Box 4000, Route 206 and Province Line Road, Princeton, New Jersey 08543-4000, for and on behalf of itself and its Affiliates ("BMS"), and Seattle Genetics, Inc., a corporation duly organized and existing under the laws of the State of Delaware, having offices at 22215 26th Avenue, SE, Bothell, Washington 98021 ("SGI").

LICENSE AGREEMENT No. 651-O1.LIC
License Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research • Arizona

THIS AGREEMENT (the "Agreement"), made this 3rd day of February, 2000 (the "EFFECTIVE DATE"), is by and between the ARIZONA BOARD OF REGENTS, a body corporate of the State of Arizona, acting on behalf of and for ARIZONA STATE UNIVERSITY, of Tempe, Arizona ("ASU") and Seattle Genetics, Inc., a corporation organized under the laws of Delaware having its principal place of business located at 22215 26th Avenue SE, Bothell, Washington 98021 ("LICENSEE").

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Seattle Genetics Inc /Wa • December 5th, 2000 • Services-commercial physical & biological research • California

This Agreement, dated as of 24 January 2000 is between Genentech, Inc., a Delaware corporation having a principal place of business 1 DNA Way, South San Francisco, California 94080 (hereinafter "Genentech") and Seattle Genetics Inc., having a place of business at 22215 26th Ave. S.E. Bothell, WA 98021 (hereinafter "Licensee').

LICENSE AGREEMENT
License Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research • California

THIS LICENSE AGREEMENT dated as of June 8, 1993 (the "Agreement"), is entered into between IXSYS, INC., a Delaware corporation ("Ixsys"), having a place of business located at 3550 General Atomics Court, Suite L-103, San Diego, California 92121, and BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation ("Bristol-Myers"), having a place of business located at Route 206 and Provinceline Road, Princeton, New Jersey 08543-4000.

LICENSE AGREEMENT
License Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research • Washington

This License Agreement (this "Agreement"), is entered into as of June 14, 1998 (the "Effective Date") by and between MABTECH AB, formed under the laws of Sweden ("MAB") and SEATTLE GENETICS, INC., a Delaware corporation ("SGI").

CONTRACT MANUFACTURING AGREEMENT
Contract Manufacturing Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research • Washington

This CONTRACT MANUFACTURING AGREEMENT (the "Agreement") is entered into as of October 16, 2000 (the "Effective Date"), by and between ICOS Corporation ("ICOS"), a corporation organized and existing under the laws of the State of Delaware and having its principal place of business at 22021 20th Avenue SE, Bothell, WA 98021 USA and Seattle Genetics, Inc. ("SGI"), a corporation organized and existing under the laws of the State of Delaware and having its principal place of business at 22215 26th Avenue S.E., Suite 3000, Bothell, WA 98021.

RESEARCH AGREEMENT
Research Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research • California

THIS RESEARCH AGREEMENT dated as of June 8, 1993 (the "Agreement"), is entered into between IXSYS, INC., a Delaware corporation ("Ixsys"), having a place of business located at 3550 General Atomics Court, Suite L-103, San Diego, California 92121, and BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation ("Bristol-Myers"), having a place of business located at Route 206 and Province Line Road, Princeton, New Jersey 08543-4000.

NON-EXCLUSIVE LICENSE AGREEMENT
Non-Exclusive License Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research • New Jersey

THIS AGREEMENT, effective as of Sept. 29, 1998, is between Creative BioMolecules, Inc. a corporation of the State of Delaware (CBM) having its principal place of business at 35 South Street, Hopkinton, Massachusetts 01748, and Seattle Genetics, Inc., a corporation of the State of Delaware (SG) having a principal place of business at 22215 26th Avenue SE, Bothell, Washington 98021.

AMENDMENT NO. 1 TO LICENSE AGREEMENT BETWEEN UNIVERSITY OF MIAMI AND SEATTLE GENETICS, INC.
License Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research

This Amendment No. 1 to License Agreement (the "Amendment") is made as of August 4, 2000 by and between University of Miami and its School of Medicine, whose principal place of business is at 1600 N.W. 10th Avenue, Miami, Florida 33136 ("Licensor"), and Seattle Genetics, Inc., a Delaware corporation having offices at 22215 26th Avenue SE, Bothell, WA 98021 ("Licensee").

LICENSE AGREEMENT
License Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research • New York

This Agreement is effective as January 1, 1998, and is by and between Brookhaven Science Associates, LLC. ("Licensor"), operator of Brookhaven National Laboratory, Upton, New York 11973, under contract with the U. S. Department of Energy, and Seattle Genetics, Inc., ("Licensee") having a principal place of business at 22215 26th Avenue S. E., Bothell, WA 98021.

SUBLEASE
Seattle Genetics Inc /Wa • December 5th, 2000 • Services-commercial physical & biological research • Washington

THIS SUBLEASE ("Sublease") is made and entered into this 5th day of February, 1999, by and between ICOS CORPORATION, a Delaware corporation ("Sublandlord"), and SEATTLE GENETICS, INC., a Delaware corporation ("Subtenant"). The parties desire that Sublandlord sublease to Subtenant and Subtenant sublease from Sublandlord the Premises defined below, on the terms and conditions contained in this Sublease. Sublandlord and Subtenant agree as follows:

CONFIDENTIAL AMENDMENT NO. 1 TO PUBLIC HEALTH SERVICE PATENT & LICENSE AGREEMENT—NONEXCLUSIVE
License Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research

This Amendment No. 1 to Patent License Agreement OTT Reference Number: L-156- 98/0 Nonexclusive (the "Amendment") is made as of July 14, 2000 by and between The National Institutes of Health ("NIH"), the Centers for Disease Control and Prevention ("CDC") or the Food and Drug Administration ("FDA") (collectively referred to as "PHS") and Seattle Genetics, Inc., a Delaware corporation ("SGI").

AMENDMENT TO LICENSE AGREEMENT BETWEEN BRISTOL-MYERS SQUIBB COMPANY AND SEATTLE GENETICS, INC.
License Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research

This Amendment to License Agreement (the "Amendment") is made as of July 26, 2000 by and between Bristol-Myers Squibb Company, a Delaware corporation having offices at P.O. Box 4000, Route 206 and Province Line Road, Princeton, New Jersey, 08543-4000 ("BMS"), and Seattle Genetics, Inc., a Delaware corporation having offices at 22215 26th Avenue SE, Bothell, WA 98021 ("SGI")

July 29, 1999
Seattle Genetics Inc /Wa • December 5th, 2000 • Services-commercial physical & biological research

This letter sets forth the agreement of Bristol-Myers Squibb Company ("BMS") and Seattle Genetics, Inc. ("SGI") to amend that certain License Agreement dated March 30, 1998 between BMS and SGI (the "Agreement") as set forth herein.

FIRST AMENDMENT TO THE LICENSE AGREEMENT
License Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research

This First Amendment (the "Amendment") to the License Agreement ("License Agreement") is made effective as of January 31, 2000 (the "Effective Date") by and between MABTECH AB, formed under the laws of Sweden ("MAB") and SEATTLE GENETICS, INC., a Delaware corporation ("SGI").

SEMI-EXCLUSIVE LICENSE AGREEMENT
Semi-Exclusive License Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research • New Jersey

THIS AGREEMENT, effective as Sept. 30, 1993, is between Enzon, Inc. a corporation of the State of Delaware (ENZON) having its principal place of business at 40 Kingsbridge Road, Piscataway, NJ 08854-3998, and Bristol-Myers Squibb Company, a corporation of the State of Delaware (BMS) having a principal place of business at Route 206 and Province Line Road, Princeton, NJ 08540.

DEVELOPMENT AGREEMENT
Development Agreement • December 5th, 2000 • Seattle Genetics Inc /Wa • Services-commercial physical & biological research • Massachusetts

This Agreement is made and entered into on this 20th day of July, 1999 ("Effective Date") between Seattle Genetics, Inc. ("Seattle Genetics"), a Delaware corporation with offices at 22215 26th Avenue, Bothell, WA 98021 and GTC Corporation ("GTC"), a Massachusetts corporation with offices at 175 Crossing Boulevard, Framingham, MA 01701-9322.

CONFIDENTIAL PUBLIC HEALTH SERVICE PATENT LICENSE AGREEMENT—NONEXCLUSIVE COVER PAGE
Seattle Genetics Inc /Wa • December 5th, 2000 • Services-commercial physical & biological research • District of Columbia

This Patent License Agreement, hereinafter referred to as the "Agreement", consists of this Cover Page, an attached Agreement, a Signature Page, Appendix A (List of Patent(s) and/or Patent Application(s)), Appendix B (Fields of Use and Territory), Appendix C (Royalties), Appendix D (Modifications), Appendix E (Benchmarks), and Appendix F (Commercial Development Plan). The Parties to this Agreement are:

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