0000912057-02-039039 Sample Contracts

STOCK PURCHASE AGREEMENT
Stock Purchase Agreement • October 18th, 2002 • Biotechnology Value Fund L P • Investment advice • Delaware

This STOCK PURCHASE AGREEMENT (the "Agreement") is entered into as of October 11, 2002 by and between BB BioVentures LP, a Delaware limited partnership (the "BioVentures Fund"), MPM BioVentures Parallel Fund, L.P., a Delaware limited partnership (the "Parallel Fund"), and MPM Asset Management Investors 1999 LLC, a Delaware limited liability company (the "Co-Investment Fund" and, collectively with the BioVentures Fund and the Parallel Fund, the "Sellers") ("Seller"), and BIOTECHNOLOGY VALUE FUND, L.P., a Delaware limited partnership ("BVF"), BIOTECHNOLOGY VALUE FUND II, L.P., a Delaware limited partnership ("BVF II"), BVF INVESTMENTS L.L.C., a Delaware limited liability company ("BVF Investments") and ZIFF ASSET MANAGEMENT, L.P., a Delaware limited partnership ("Ziff") and collectively with BVF, BVF II and BVF Investments, "BUYER").

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AGREEMENT REGARDING JOINT FILING
Joint Filing Agreement • October 18th, 2002 • Biotechnology Value Fund L P • Investment advice

The undersigned, Biotechnology Value Fund, L.P., a Delaware limited partnership, Biotechnology Value Fund II, L.P., a Delaware limited partnership, BVF Investments, L.L.C., a Delaware limited liability company, BVF Partners L.P., a Delaware limited partnership, and BVF Inc., a Delaware corporation, hereby agree and acknowledge that the information required by Schedule 13D, to which this Agreement is attached as an exhibit, is filed on behalf of each of them. The undersigned further agree that any amendments or supplements thereto shall also be filed on behalf of each of them.

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