0000912057-02-042531 Sample Contracts

REVISED AND RESTATED ISIS 3521 SUPPLY AGREEMENT
Supply Agreement • November 15th, 2002 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

Starting January 2003, and annually thereafter, the MWG will calculate and set the Prepayment Amounts to be inserted in the table above. The Prepayment Amounts will be calculated by [***]

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LOAN AGREEMENT
Loan Agreement • November 15th, 2002 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

THIS LOAN AGREEMENT (the "Agreement") is entered into as of the 30th day of September 2002, (the "Effective Date"), by and between Eli Lilly and Company, an Indiana corporation ("Lilly"), and Isis Pharmaceuticals, Inc., a Delaware corporation ("Isis").

AMENDMENT NO. 1 TO ISIS PHARMACEUTICALS, INC. 10B5-1 TRADING PLAN
10b5-1 Trading Plan • November 15th, 2002 • Isis Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment No. 1 to 10b5-1 Trading Plan (the "Amendment"), is effective as of June 7, 2002 ("Effective Date") between ISIS PHARMACEUTICALS, INC., a Delaware corporation ("Isis"), and GOLDEN TRIANGLE SECURITIES LLC ("Broker").

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