10b5-1 Trading Plan Sample Contracts

AMENDED AND RESTATED ISIS PHARMACEUTICALS, INC. 10B5-1 TRADING PLAN
10b5-1 Trading Plan • November 5th, 2013 • Isis Pharmaceuticals Inc • Pharmaceutical preparations

This Amended and Restated 10b5-1 Trading Plan, (the “Trading Plan”), between ISIS PHARMACEUTICALS, INC. (“Isis”) and INSIGHT SECURITIES, INC. (“Broker”), is entered into effective September 12, 2013 (the “A&R Effective Date”). As of the Effective Date, this Trading Plan amends, restates and supersedes the previous 10b5-1 Trading Plan dated September 13, 2007 between Isis and Broker. Capitalized terms not otherwise defined herein will have the meanings given to them in Exhibit A attached hereto.

Sample 1
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RESTATED ISIS PHARMACEUTICALS, INC. 10B5-1 TRADING PLAN
10b5-1 Trading Plan • March 31st, 2003 • Isis Pharmaceuticals Inc • Pharmaceutical preparations

This 10b5-1 Trading Plan, (the "Trading Plan"), between Isis Pharmaceuticals, Inc. ("Isis") and Golden Triangle Securities llc ("Broker"), is entered into on February 22, 2002. Capitalized terms not otherwise defined herein will have the meanings given to them in Exhibit A attached hereto.

Sample 1
RESTATED ISIS PHARMACEUTICALS, INC. 10B5-1 TRADING PLAN
10b5-1 Trading Plan • November 9th, 2005 • Isis Pharmaceuticals Inc • Pharmaceutical preparations

This 10b5-1 Trading Plan, (the “Trading Plan”), between ISIS PHARMACEUTICALS, INC. (“Isis”) and HORWITZ & ASSOCIATES, INC (“Broker”), is entered into effective September 30, 2005 (the “Effective Date”). Capitalized terms not otherwise defined herein will have the meanings given to them in Exhibit A attached hereto.

Sample 1
AMENDMENT NO. 1 TO ISIS PHARMACEUTICALS, INC. 10B5-1 TRADING PLAN
10b5-1 Trading Plan • November 15th, 2002 • Isis Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment No. 1 to 10b5-1 Trading Plan (the "Amendment"), is effective as of June 7, 2002 ("Effective Date") between ISIS PHARMACEUTICALS, INC., a Delaware corporation ("Isis"), and GOLDEN TRIANGLE SECURITIES LLC ("Broker").

Sample 1
ISIS PHARMACEUTICALS, INC. 10B5-1 TRADING PLAN This 10b5-1 Trading Plan, (the "Trading Plan"), between ISIS PHARMACEUTICALS, INC. ("Isis") and GOLDEN TRIANGLE SECURITIES LLC ("Broker"), is entered into on February 26, 2002. Capitalized terms not...
10b5-1 Trading Plan • April 1st, 2002 • Isis Pharmaceuticals Inc • Pharmaceutical preparations
Sample 1
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