0000922423-10-000425 Sample Contracts

SECOND AMENDMENT TO MANUFACTURING AGREEMENT
Manufacturing Agreement • September 20th, 2010 • Helix BioPharma Corp • Pharmaceutical preparations

This second amendment agreement (“Second Amendment”) is made this 18 day of November, 2009 by and between Helix Biopharma Corporation (“Helix”), a corporation organized and existing under the laws of Canada and having its principal offices located at 305 Industrial Parkway South, Unit 3, Aurora, Ontario, L4G 6X7, and Contract Pharmaceuticals Limited Niagara (“CPL”), a corporation organized and existing under the laws of Delaware and having a place of business located at 100 Forest Avenue, Buffalo, New York, 14213.

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