0000936392-08-000015 Sample Contracts

OREXIGEN THERAPEUTICS, INC. REGISTRATION RIGHTS WAIVER AND AMENDMENT January 6, 2008
Registration Rights Waiver and Amendment • January 7th, 2008 • Orexigen Therapeutics, Inc. • Pharmaceutical preparations

Reference is made to the Second Amended and Restated Investors’ Rights Agreement (the “Investors’ Rights Agreement”), dated as of November 20, 2006, by and among Orexigen Therapeutics, Inc. (the “Company”) and the investor parties thereto (the “Holders”). All capitalized terms used herein and not otherwise defined shall have the meanings assigned to such terms in the Investors’ Rights Agreement.

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