Exhibit 4.1 ROCHE HOLDINGS, INC. (a Delaware corporation) $1,506,342,000 Principal Amount at Maturity Liquid Yield Option(TM) Notes due 2015 (Zero Coupon) PRIVATE PLACEMENT PURCHASE AGREEMENTPrivate Placement Purchase Agreement • August 4th, 2000 • Genentech Inc • Pharmaceutical preparations • New York
