0000950123-11-050020 Sample Contracts

13,640,000 Shares1 NANOSPHERE, INC. Common Stock PURCHASE AGREEMENT
Purchase Agreement • May 13th, 2011 • Nanosphere Inc • Surgical & medical instruments & apparatus • New York

Nanosphere, Inc., a Delaware corporation (the “Company”), proposes to sell to the several underwriters (the “Underwriters”) named in Schedule I hereto for whom Piper Jaffray & Co. is acting as representative (the “Representative”), an aggregate of 13,640,000 shares (the “Firm Shares”) of common stock, $0.01 par value per share (the “Common Stock”), of the Company. The Company has also granted to the several Underwriters an option to purchase up to an aggregate of 2,046,000 additional shares of Common Stock, on the terms and for the purposes set forth in Section 3 hereof (the “Option Shares”). The Firm Shares and any Option Shares purchased pursuant to this Purchase Agreement are herein collectively called the “Securities.”

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