0000950133-05-004551 Sample Contracts

IOMAI CORPORATION REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations • District of Columbia

This REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made as of March 30, 1999, by and between IOMAI CORPORATION, a Delaware corporation (the “Company”), MARYLAND HEALTH CARE PRODUCT DEVELOPMENT CORPORATION, a Maryland non-profit corporation (“MHPDC”) (the “Agreement”).

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Pfénex Expression Technology™ COMMERCIAL LICENSE AGREEMENT
Commercial License Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations • Delaware

This Agreement is effective as of the latest date of signing below and is by and between Dow Global Technologies Incorporated (“Dow”), a Michigan corporation having its principal offices at 2030 Dow Center, Midland, MI, 48674 USA and Iomai Corporation, a Delaware corporation (“Licensee”) having a principal place of business at 20 Firstfield Road Suite 250, Gaithersburg, MD 20878 USA

IOMAI CORPORATION REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations • Delaware

This REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made as of January 4, 2001, by and between IOMAI CORPORATION, a Delaware corporation (the “Company”), and Alexandria Real Estate Equities, L.P., a Delaware limited partnership(“ARE”).

OPTION AGREEMENT
Option Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations • New York

This Option Agreement (this “Agreement”) is made as of the 4th day of December, 2002, (“Effective Date”) by and between Iomai Corporation, a Delaware corporation (“Iomai”) and Elan Corporation, plc, a public limited liability company incorporated under the laws of Ireland (“Elan”) (each a “Party” and collectively, the “Parties”).

SECOND AMENDMENT TO LEASE
Lease • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations

This Second Amendment (the “Second Amendment”) to Lease is made as of April 14, 2003, by and between ARE-20/22/1300 FIRSTFIELD QUINCE ORCHARD, LLC, a Delaware limited liability company, having an address at 135 North Los Robles Avenue, Suite 250, Pasadena, California 91101 (“Landlord”), and IOMAI CORPORATION, a Delaware corporation, having an address at 20 Firstfield Road, Gaithersburg, Maryland 20878 (“Tenant”).

LEASE AGREEMENT
Lease Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations

THIS LEASE AGREEMENT is made this 18th day of December, 2000, between ARE-20/22/1300 FIRSTFIELD QUINCE ORCHARD, LLC, a Delaware limited liability company (“Landlord”), and IOMAI CORPORATION, a Delaware corporation (“Tenant”).

VOTING TRUST AND ESCROW AGREEMENT
Voting Trust and Escrow Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations • Delaware

This Voting Trust and Escrow Agreement (this “Agreement”) is made and entered into on April 6, 2001, by and between IOMAI CORPORATION, a Delaware corporation (“Iomai”) and MdBio, Inc., a Maryland non-profit organization (“MdBio”), as escrow agent and as trustee for and on behalf of WALTER REED ARMY INSTITUTE OF RESEARCH, a representative of the United States of America (“WRAIR”).

April 6, 2001
License Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations

Re: License Agreement made effective as of December 15, 1997 (“Master License Agreement”), between Walter Reed Army Institute of Research, a representative of the United States of America (“WRAIR”), and Medical Technology and Practice Patterns Institute, a District of Columbia corporation (“MTPPI”), as amended pursuant to that certain Novation Agreement dated April 22, 1999 (the “Novation”), whereby MTPPI transferred all of its rights, interests, duties and obligations under the Master license Agreement to Iomai Corporation (the “Company”)

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations • New York

This REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of April 6, 2001, by and between Iomai Corporation, a Delaware corporation (the “Company”) and MDBio, Inc., a Maryland non-profit organization, acting as trustee (the “Voting Trustee”) for and on behalf of Walter Reed Army Institute of Research, a representative of the United States of America (“WRAIR”).

Iomai Corporation 1999 Stock Incentive Plan (As Adopted and Effective August 10, 1999)
1999 Stock Incentive Plan • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations
Contract
Nonqualified Stock Option Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations • Delaware

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED OR QUALIFIED UNDER THE SECURITIES ACT OF 1933 OR THE SECURITIES LAWS OF ANY STATE, AND MAY BE OFFERED AND SOLD ONLY IF REGISTERED AND QUALIFIED PURSUANT TO THE RELEVANT PROVISIONS OF FEDERAL AND STATE SECURITIES LAWS OR IF THE COMPANY IS PROVIDED AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT REGISTRATION AND QUALIFICATION UNDER FEDERAL AND STATE SECURITIES LAWS IS NOT REQUIRED.

FIRST AMENDMENT TO LEASE
Lease • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations

This First Amendment (this “First Amendment”) to Lease is made as of November 29, 2001, by and between ARE-20122/1300 FIRSTFIELD QUINCE ORCHARD, LLC, a Delaware limited liability company, having an address at 135 North Los Robles Avenue, Suite 250, Pasadena, California 91101 (“Landlord”), and IOMAI CORPORATION, a Delaware Corporation, having an address at 20 Firstfield Road, Gaithersburg, Maryland 20878 (“Tenant”). Any initially capitalized terms used but not defined herein shall have the meanings given to them in the Lease (as hereinafter defined).

EMPLOYMENT AGREEMENT
Employment Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations

THIS EMPLOYMENT AGREEMENT (the “Agreement”) is entered into as of May 18, 2000 (the “Effective Date”), by and between Stanley Erck, an individual resident of the State of Massachusetts (“you”) and Iomai Corporation, a Delaware corporation (the “Company”).

INVESTOR RIGHTS AGREEMENT BY AND AMONG IOMAI CORPORATION AND THE PURCHASERS LISTED ON EXHIBIT A HERETO December 4, 2002
Investor Rights Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations • Delaware

This INVESTOR RIGHTS AGREEMENT (this “Agreement”), dated as of December 4, 2002 is entered into by and among Iomai Corporation, a Delaware corporation (the “Company”), and the individuals and entities listed on Exhibit A hereto (collectively, the “Purchasers”).

MASTER SECURITY AGREEMENT NO. 3081038 DATED AS OF SEPTEMBER 26, 2003 (“AGREEMENT”)
Master Security Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations • Virginia

THIS AGREEMENT is between Oxford Finance Corporation (together with its successors and assigns, if any, “Secured Party”) and Iomai Corporation (“Debtor”). Secured Party has an office at 133 N. Fairfax Street, Alexandria, VA 22314. Debtor is a corporation organized and existing under the laws of the state of Delaware. Debtor’s mailing address and chief place of business is 20 Firstfield Road, Suite 250, Gaithersburg, MD 20878.

Contract
Incentive Stock Option Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations • Delaware

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED OR QUALIFIED UNDER THE SECURITIES ACT OF 1933 OR THE SECURITIES LAWS OF ANY STATE, AND MAY BE OFFERED AND SOLD ONLY IF REGISTERED AND QUALIFIED PURSUANT TO THE RELEVANT PROVISIONS OF FEDERAL AND STATE SECURITIES LAWS OR IF THE COMPANY IS PROVIDED AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT REGISTRATION AND QUALIFICATION UNDER FEDERAL AND STATE SECURITIES LAWS IS NOT REQUIRED.

THIRD AMENDMENT TO LEASE
Lease • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations

This Third Amendment (the “Third Amendment“) to Lease is made as of August 28, 2003, by and between ARE-20/22/1300 FIRSTFIELD QUINCE ORCHARD, LLC, a Delaware limited liability company, having an address at 135 North Los Robles Avenue, Suite 250, Pasadena, California 91101 (“Landlord”), and IOMAI CORPORATION, a Delaware corporation, having an address at 20 Firstfield Road, Gaithersburg, Maryland 20878 (“Tenant”).

IOMAI CORPORATION Stock Purchase Warrant
Stock Purchase Warrant • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations • Delaware

THIS WARRANT is issued in connection with the closing of the private placement of IOMAI CORPORATION, a Delaware corporation (the “Company”), of its Series C Preferred Stock, par value $0.01 per share (the “Series C Preferred Stock”) effective this 4th day of December, 2002, by the Company to FRIEDMAN BILLINGS RAMSEY & CO., INC. or any subsequent assignee or transferee (hereinafter referred to collectively as the “Holder” or “Holders”).

AMENDED AND RESTATED LICENSE AGREEMENT
License Agreement • October 11th, 2005 • Iomai Corp • Pharmaceutical preparations • District of Columbia

THIS AMENDED AND RESTATED LICENSE AGREEMENT (this “Agreement”) is effective as of the Effective Date (as defined below), by and between (i) the WALTER REED ARMY INSTITUTE OF RESEARCH (“Licensor”), as the representative of the United States of America, and (ii) IOMAI CORPORATION (“Licensee”), a corporation of Delaware, having a principal place of business at 2421 Pennsylvania Avenue, N.W., Washington, DC 20037-1718.

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