0000950135-04-001250 Sample Contracts

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EXHIBIT 10.16 RESEARCH AND DEVELOPMENT AGREEMENT
Research and Development Agreement • March 12th, 2004 • Arqule Inc • Pharmaceutical preparations • Massachusetts
RECITALS
Termination of Agreement • March 12th, 2004 • Arqule Inc • Pharmaceutical preparations
Amendment of the December 18, 2001 Collaboration Agreement
2001 Collaboration Agreement • March 12th, 2004 • Arqule Inc • Pharmaceutical preparations

This refers to the agreement between ArQule, Inc. (“ArQule”) and Pfizer Inc and its Affiliates (“Pfizer”) dated December 18, 2001 (the “Agreement”). ArQule and Pfizer hereby agree to amend the Agreement as follows:

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