0001047469-02-006968 Sample Contracts

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • December 13th, 2002 • Biotechnology Value Fund L P • Investment advice • California

SECURITIES PURCHASE AGREEMENT (the "Agreement"), dated as of December 3, 2002, by and among Micrologix Biotech Inc., a British Columbia Company, with headquarters located at 3650 Wesbrook Mall, Vancouver, British Columbia V6S 2L2 (the "Company"), and the Biotechnology Value Fund, L.P., located at One Sansome Street, San Francisco, CA 94104 ("BVF") and other accredited investors resident in the United States and listed on the Schedule of Buyers attached hereto (individually, a "Buyer" and collectively, the "Buyers").

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AGREEMENT REGARDING JOINT FILING
Joint Filing Agreement • December 13th, 2002 • Biotechnology Value Fund L P • Investment advice

The undersigned, Biotechnology Value Fund, L.P., a Delaware limited partnership, Biotechnology Value Fund II, L.P., a Delaware limited partnership, BVF Investments, L.L.C., a Delaware limited liability company, BFV Partners L.P., a Delaware limited partnership, and BVF Inc., a Delaware corporation, hereby agree and acknowledge that the information required by Schedule 13D, to which this Agreement is attached as an exhibit, is filed on behalf of each of them. The undersigned further agree that any amendments or supplements thereto shall also be filed on behalf of each of them.

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