0001047469-04-007808 Sample Contracts

ROBODESIGN INTERNATIONAL DEVELOPMENT AGREEMENT
Development Agreement • March 15th, 2004 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • California

This Development Agreement (the "Agreement") is entered into this day of November, 2003 (the "Effective Date"), by and between RoboDesign International, Inc., a Delaware corporation with its principal place of business located at 5920 Pasteur Court, Carlsbad, CA 92008 ("RoboDesign"), and Isis Pharmaceuticals, Inc., a Delaware corporation with its principal place of business located at 2292 Faraday Avenue, Carlsbad, CA 92008, ("Isis").

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LOAN AND SECURITY AGREEMENT between SILICON VALLEY BANK and ISIS PHARMACEUTICALS, INC. December 15, 2003 $32,000,000
Loan and Security Agreement • March 15th, 2004 • Isis Pharmaceuticals Inc • Pharmaceutical preparations

This LOAN AND SECURITY AGREEMENT dated December 15, 2003, between SILICON VALLEY BANK ("Bank"), whose address is 3003 Tasman Drive, Santa Clara, California 95054 and ISIS PHARMACEUTICALS, INC. ("Borrower"), whose address is 2292 Faraday Avenue, Carlsbad, CA 92008, provides the terms on which Bank will lend to Borrower and Borrower will repay Bank. The parties agree as follows:

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