0001047469-04-009648 Sample Contracts

CONSULTING AGREEMENT EFFECTIVE DATE: March 25, 2004
Consulting Agreement • March 29th, 2004 • Cypress Bioscience Inc • Biological products, (no disgnostic substances) • California

This Consulting Agreement (the "Agreement") is made by and between Cypress Bioscience, Inc. ("Client"), a Delaware corporation, and Larry Kessel ("Consultant").

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LICENSE AND COLLABORATION AGREEMENT
License and Collaboration Agreement • March 29th, 2004 • Cypress Bioscience Inc • Biological products, (no disgnostic substances) • New York

THIS LICENSE AND COLLABORATION AGREEMENT (this "Agreement") is entered into as of January 9, 2004 (the "Effective Date") by and between FOREST LABORATORIES IRELAND LIMITED, an Irish corporation ("Forest"), having its principal executive offices at Clonshaugh Industrial Estate, Clonshaugh, Dublin 17, Republic of Ireland, and CYPRESS BIOSCIENCE, INC., a Delaware corporation ("Cypress"), having offices at 4350 Executive Drive, Suite 325, San Diego, CA 92121, United States of America.

EMPLOYMENT AGREEMENT
Employment Agreement • March 29th, 2004 • Cypress Bioscience Inc • Biological products, (no disgnostic substances) • California

THIS EMPLOYMENT AGREEMENT (this "Agreement") is made and entered into effective as of this 4th day of February 2004 (the "Effective Date"), by and between CYPRESS BIOSCIENCE, INC., a Delaware corporation (the "Company") and Denise Woolard (the "Employee").

THIRD RESTATED LICENSE AGREEMENT
License Agreement • March 29th, 2004 • Cypress Bioscience Inc • Biological products, (no disgnostic substances) • New York

THIS THIRD RESTATED LICENSE AGREEMENT (this "Agreement") is entered into as of January 9, 2004 (the "Restatement Date") by and between PIERRE FABRE MÉDICAMENT, organized under the laws of France having an address of 45, place Abel-Gance, 92654 Boulogne Cedex, France ("Pierre Fabre"), and CYPRESS BIOSCIENCE, INC., a Delaware corporation having an address of 4350 Executive Drive, Suite 325, San Diego, CA 92121, United States of America ("Cypress"). This Agreement amends and restates in its entirety the Second Restated License Agreement between Pierre Fabre and Cypress dated May 30, 2003 (the "Prior Agreement").

FIRST RESTATED TRADEMARK AGREEMENT
Trademark Agreement • March 29th, 2004 • Cypress Bioscience Inc • Biological products, (no disgnostic substances) • New York

THIS FIRST RESTATED TRADEMARK AGREEMENT (this "Agreement") is entered into as of January 9, 2004 (the "Effective Date") by and between Pierre Fabre Médicament, organized under the laws of France having an address of 45, place Abel-Gance, 92654 Boulogne cedex, France ("Pierre Fabre"), and Cypress Bioscience, Inc., a Delaware corporation having an address of 4350 Executive Drive, Suite 325, San Diego, CA 92121, U.S.A. ("Cypress") and amends and restates in its entirety the Trademark Agreement between Pierre Fabre and Cypress dated August 1, 2001 (the "Prior Agreement"). Capitalized terms used in this Agreement that are not otherwise defined shall have the meaning set forth in the Third Restated License Agreement of even date herewith between Cypress and Pierre Fabre (the "License Agreement").

LETTER AGREEMENT
Letter Agreement • March 29th, 2004 • Cypress Bioscience Inc • Biological products, (no disgnostic substances) • New York

THIS LETTER AGREEMENT (this "Agreement") is entered into as of January 9, 2004 (the "Effective Date") by and among FOREST LABORATORIES IRELAND LIMITED, an Irish corporation ("Forest"), having offices at Clonshaugh Industrial Estate, Clonshaugh, Dublin 17, Republic of Ireland, CYPRESS BIOSCIENCE, INC., a Delaware corporation ("Cypress"), having offices at 4350 Executive Drive, Suite 325, San Diego, CA 92121 and PIERRE FABRE MÉDICAMENT, organized under the laws of France ("Pierre Fabre"), having offices at 45, place Abel-Gance, 92654 Boulogne Cedex, France.

PURCHASE AND SUPPLY AGREEMENT
Purchase and Supply Agreement • March 29th, 2004 • Cypress Bioscience Inc • Biological products, (no disgnostic substances) • New York

THIS PURCHASE AND SUPPLY AGREEMENT (this "Agreement") is made and entered into as of January 9, 2004 (the "Effective Date"), by and between PIERRE FABRE MÉDICAMENT, organized under the laws of France having an address of 45, place Abel-Gance, 92654 Boulogne Cedex, France ("Pierre Fabre"), and CYPRESS BIOSCIENCE, INC., a Delaware corporation having an address of 4350 Executive Drive, Suite 325, San Diego, CA 92121, U.S.A. ("Cypress").

Side Letter Agreement
Cypress Bioscience Inc • March 29th, 2004 • Biological products, (no disgnostic substances)

Letter Agreement dated of even date herewith among Forest Laboratories Ireland Limited, Cypress Bioscience, Inc. and Pierre Fabre Medicament

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