0001047469-04-018954 Sample Contracts

GENZYME CORPORATION and American Stock Transfer & Trust Company, Rights Agent Fourth Amended and Restated Renewed Rights Agreement Dated as of May 28, 2004
Renewed Rights Agreement • May 28th, 2004 • Genzyme Corp • Biological products, (no disgnostic substances) • Massachusetts

This Agreement amends, restates and supersedes the Renewed Rights Agreement dated as of March 16, 1999 (the "Renewed Agreement") between the Company and the Rights Agent as it was amended and restated by the Amended and Restated Renewed Rights Agreement dated as of June 10, 1999 (the "First Restated Agreement"), the Second Amended and Restated Renewed Rights Agreement dated as of December 18, 2000 (the "Second Amended Agreement") as adjusted by the Certificate of Adjustment dated as of June 1, 2001 and the Third Amended and Restated Renewed Rights Agreement dated as of June 30, 2003 (the "Third Amended Agreement").

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