0001047469-07-003832 Sample Contracts

SIRTRIS PHARMACEUTICALS, INC. [ ] Shares of Common Stock Underwriting Agreement
Underwriting Agreement • May 8th, 2007 • Sirtris Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

Sirtris Pharmaceuticals, Inc., a Delaware corporation (the "Company"), proposes to issue and sell to the several Underwriters listed in Schedule 1 hereto (the "Underwriters"), for whom you are acting as representatives (the "Representatives"), an aggregate of [ ] shares of Common Stock, par value $0.001 per share, of the Company (the "Underwritten Shares") and, at the option of the Underwriters, up to an additional [ ] shares of Common Stock of the Company (the "Option Shares"). The Underwritten Shares and the Option Shares are herein referred to as the "Shares". The shares of Common Stock of the Company to be outstanding after giving effect to the sale of the Shares are herein referred to as the "Stock".

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