0001047469-10-004633 Sample Contracts

AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • May 3rd, 2010 • Vertex Pharmaceuticals Inc / Ma • Pharmaceutical preparations • Massachusetts

This Amended and Restated Employment Agreement (this “Agreement”) amends and restates, effective as of the 5th day of February, 2010, that certain Employment Agreement made and entered into as of the 11th day of February, 2008, as amended by that certain Amendment to Employment Agreement entered into as of the 27th day of December, 2008 (collectively, the “Original Agreement”) by and between Vertex Pharmaceuticals Incorporated, a Massachusetts corporation (together with its successors and assigns, the “Company”), and Peter Mueller (the “Executive”).

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VERTEX PHARMACEUTICALS INCORPORATED
Change of Control Agreement • May 3rd, 2010 • Vertex Pharmaceuticals Inc / Ma • Pharmaceutical preparations • Massachusetts
AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • May 3rd, 2010 • Vertex Pharmaceuticals Inc / Ma • Pharmaceutical preparations • Massachusetts

This Amended and Restated Employment Agreement (this “Agreement”) amends and restates, effective as of the 5th day of February, 2010, that certain Employment Agreement made and entered into as of the 11th day of February, 2008, as amended by that certain Amendment to Employment Agreement entered into as of the 29th day of December, 2008 (collectively, the “Original Agreement”) by and between Vertex Pharmaceuticals Incorporated, a Massachusetts corporation (together with its successors and assigns, the “Company”), and Lisa Kelly-Croswell (the “Executive”).

SECOND AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • May 3rd, 2010 • Vertex Pharmaceuticals Inc / Ma • Pharmaceutical preparations • Massachusetts

This Second Amended and Restated Employment Agreement (the “Agreement”) amends and restates, effective as of this 5th day of February, 2010, that certain Amended and Restated Employment Agreement made and entered into as of the 8th day of November, 2004, as amended by that certain Amendment No. 1 entered into as of the 11th day of February, 2008, and that certain Amendment No. 2 entered into as of the 29th day of December, 2008 (collectively, the “Original Agreement”) by and between Vertex Pharmaceuticals Incorporated, a Massachusetts corporation (together with its successors and assigns, the “Company”), and Kenneth S. Boger (the “Executive”).

AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • May 3rd, 2010 • Vertex Pharmaceuticals Inc / Ma • Pharmaceutical preparations • Massachusetts

This Amended and Restated Employment Agreement (this “Agreement”) amends and restates, effective as of this 5th day of February, 2010, that certain Employment Agreement made and entered into as of the 11th day of February, 2008, as amended by that certain Amendment to Employment Agreement entered into as of the 29th day of December, 2008 (collectively, the “Original Agreement”) by and between Vertex Pharmaceuticals Incorporated, a Massachusetts corporation (together with its successors and assigns, the “Company”), and Amit Sachdev (the “Executive”).

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