0001047469-10-005977 Sample Contracts

AMENDED AND RESTATED DEBT EXCHANGE AGREEMENT
Debt Exchange Agreement • June 16th, 2010 • Advanced Life Sciences Holdings, Inc. • Biological products, (no disgnostic substances) • Illinois

THIS AMENDED AND RESTATED DEBT EXCHANGE AGREEMENT (this “Agreement”) is entered into as of this 15th day of June, 2010 by and between ADVANCED LIFE SCIENCES HOLDINGS, INC., a Delaware corporation (the “Company”), and Michael T. Flavin (the “Maker”).

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Advanced Life Sciences Holdings, Inc. and Onyx Stock Transfer, LLC, Warrant Agent Warrant Agent Agreement Dated as of June , 2010
Warrant Agent Agreement • June 16th, 2010 • Advanced Life Sciences Holdings, Inc. • Biological products, (no disgnostic substances) • New York

WARRANT AGENT AGREEMENT, dated as of June , 2010 (“Agreement”), between Advanced Life Sciences Holdings, Inc., a Delaware corporation (the “Company”), and Onyx Stock Transfer, LLC, a California limited liability company (the “Warrant Agent”).

ADVANCED LIFE SCIENCES HOLDINGS, INC. Form of Warrant for the Purchase of Units
Warrant Agreement • June 16th, 2010 • Advanced Life Sciences Holdings, Inc. • Biological products, (no disgnostic substances)

THIS CERTIFIES that, for consideration, the receipt and sufficiency of which are hereby acknowledged, and other value received, (the “Holder”) is entitled to subscribe for, and purchase from, ADVANCED LIFE SCIENCES HOLDINGS, INC., a Delaware corporation (the “Company”), upon the terms and conditions set forth herein, at any time or from time to time during the Exercise Period (as defined below), up to an aggregate of units of the Company (the “Units”), with each Unit consisting of 100 shares of the Company's common stock, par value $0.01 per share (the “Common Stock”), and 100 warrants to purchase Common Stock at an exercise price of $ per share (the “Stock Warrants”). The Units shall separate immediately upon the exercise of this Warrant and shares of Common Stock and Stock Warrants shall be issued separately. This Warrant is initially exercisable at a price of $ per Unit, subject to adjustment as described in this Warrant. The term “Exercise Price” shall mean, depending on the contex

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