0001104659-02-004376 Sample Contracts

FIRST AMENDMENT TO CONVERTIBLE DEBENTURE AND WARRANT PURCHASE AGREEMENT
Convertible Debenture and Warrant Purchase Agreement • August 23rd, 2002 • Cygnus Inc /De/ • Pharmaceutical preparations • New York

This First Amendment to Convertible Debenture and Warrant Purchase Agreement (this “Amendment”) is dated as of August 21, 2002 by and among Cygnus, Inc., a Delaware corporation (the “Company”), and each Investor, as defined below, and is made with reference to that certain Convertible Debenture and Warrant Purchase Agreement dated as of June 29, 1999 (the “Agreement”) between the Company and each of the investors named therein (together with any assignees of such investors, the “Investors”). Capitalized terms used herein without definition shall have the same meanings herein as set forth in the Agreement.

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FIRST AMENDMENT TO
Cygnus Inc /De/ • August 23rd, 2002 • Pharmaceutical preparations • New York

This First Amendment to 8.5% Convertible Debentures Due September 29, 2004 (this “Amendment”) is dated August 21, 2002, by and among Cygnus Inc., a Delaware corporation (the “Company”), and each Holder, as defined below, and is made with reference to that certain series of Debentures, as defined in the First Amendment to Convertible Debentures and Warrant Purchase Agreement dated concurrently herewith, between the Company and each holder named therein (together with any assignees of such holders, the “Holders”). Capitalized terms used herein without definition shall have the same meanings herein as set forth in the Debentures.

FIRST AMENDMENT TO
Cygnus Inc /De/ • August 23rd, 2002 • Pharmaceutical preparations • New York

This First Amendment to 8.5% Convertible Debentures Due June 29, 2004 (this “Amendment”) is dated August 21, 2002, by and among Cygnus Inc., a Delaware corporation (the “Company”), and each Holder, as defined below, and is made with reference to that certain series of Debentures, as defined in the First Amendment to Convertible Debentures and Warrant Purchase Agreement dated concurrently herewith, between the Company and each holder named therein (together with any assignees of such holders, the “Holders”). Capitalized terms used herein without definition shall have the same meanings herein as set forth in the Debentures.

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