Exhibit 4.12 REGISTRATION RIGHTS AGREEMENT ----------------------------- THIS REGISTRATION RIGHTS AGREEMENT ("AGREEMENT") is entered into as of June 29, 1999 by and between CYGNUS, INC., a Delaware corporation with offices at 400 Penobscot Drive,...Registration Rights Agreement • August 16th, 1999 • Cygnus Inc /De/ • Pharmaceutical preparations • New York
Contract Type FiledAugust 16th, 1999 Company Industry Jurisdiction
CYGNUS, INC.Cygnus Inc /De/ • August 16th, 1999 • Pharmaceutical preparations • New York
Company FiledAugust 16th, 1999 Industry Jurisdiction
ANDRights Agreement • December 14th, 1998 • Cygnus Inc /De/ • Pharmaceutical preparations • New York
Contract Type FiledDecember 14th, 1998 Company Industry Jurisdiction
RECITALSLease Agreement • November 5th, 1999 • Cygnus Inc /De/ • Pharmaceutical preparations
Contract Type FiledNovember 5th, 1999 Company Industry
CYGNUS, INC.Cygnus Inc /De/ • August 16th, 1999 • Pharmaceutical preparations • New York
Company FiledAugust 16th, 1999 Industry Jurisdiction
EXHIBIT 99.2 ASSET PURCHASE AGREEMENT BY AND BETWEENAsset Purchase Agreement • December 17th, 2004 • Cygnus Inc /De/ • Measuring & controlling devices, nec • Delaware
Contract Type FiledDecember 17th, 2004 Company Industry Jurisdiction
SUBLEASELease Agreement • April 27th, 1999 • Cygnus Inc /De/ • Pharmaceutical preparations
Contract Type FiledApril 27th, 1999 Company Industry
UNDERWRITING AGREEMENTCygnus Inc /De/ • November 12th, 1997 • Pharmaceutical preparations • New York
Company FiledNovember 12th, 1997 Industry Jurisdiction
CYGNUS, INC.Common Stock Purchase Agreement • February 4th, 1998 • Cygnus Inc /De/ • Pharmaceutical preparations • California
Contract Type FiledFebruary 4th, 1998 Company Industry Jurisdiction
RECITALSExchange Agreement • March 25th, 2004 • Cygnus Inc /De/ • Measuring & controlling devices, nec • New York
Contract Type FiledMarch 25th, 2004 Company Industry Jurisdiction
DATE]Letter Agreement • March 27th, 2001 • Cygnus Inc /De/ • Pharmaceutical preparations • California
Contract Type FiledMarch 27th, 2001 Company Industry Jurisdiction
SUPPLY AGREEMENT This Supply Agreement ("Agreement") is effective as of March 1, 2000 ("Effective Date") by and between Cygnus, Inc., a Delaware corporation, with its principal place of business at 400 Penobscot Drive, Redwood City, California 94063...Supply Agreement • July 28th, 2000 • Cygnus Inc /De/ • Pharmaceutical preparations • California
Contract Type FiledJuly 28th, 2000 Company Industry Jurisdiction
EXHIBIT 10.31 FORM OF AGREEMENT WITH EXECUTIVE OFFICER RELATING TO CHANGE OF CONTROLCygnus Inc /De/ • March 21st, 1997 • Pharmaceutical preparations
Company FiledMarch 21st, 1997 Industry
AMENDMENT AGREEMENTAmendment Agreement • March 30th, 1999 • Cygnus Inc /De/ • Pharmaceutical preparations
Contract Type FiledMarch 30th, 1999 Company Industry
RECITALSConfidential Treatment • December 30th, 1999 • Cygnus Inc /De/ • Pharmaceutical preparations • New Jersey
Contract Type FiledDecember 30th, 1999 Company Industry Jurisdiction
CYGNUS, INC. Debt Securities UNDERWRITING AGREEMENTCygnus Inc /De/ • November 12th, 1997 • Pharmaceutical preparations • New York
Company FiledNovember 12th, 1997 Industry Jurisdiction
1. Certain Definitions. Section 1 of the Rights Agreement shall be ------------------- amended as follows:Rights Agreement • December 14th, 1998 • Cygnus Inc /De/ • Pharmaceutical preparations
Contract Type FiledDecember 14th, 1998 Company Industry
This Agreement is made as of the 28th day of August, 1998 by and between Cygnus, Inc., a Delaware corporation (the "Corporation"), and Andre F. Marion ("Optionee"). W I T N E S S E T HCompensation Agreement • November 16th, 1998 • Cygnus Inc /De/ • Pharmaceutical preparations
Contract Type FiledNovember 16th, 1998 Company Industry
Exhibit 4.11 REGISTRATION RIGHTS AGREEMENT THIS REGISTRATION RIGHTS AGREEMENT ("AGREEMENT") is entered into as of June 30, 1999 by and between CYGNUS, INC., a Delaware corporation with offices at 400 Penobscot Drive, Redwood City, California 94063...Registration Rights Agreement • August 16th, 1999 • Cygnus Inc /De/ • Pharmaceutical preparations • New York
Contract Type FiledAugust 16th, 1999 Company Industry Jurisdiction
CYGNUS, INC.Cygnus Inc /De/ • August 24th, 1999 • Pharmaceutical preparations • California
Company FiledAugust 24th, 1999 Industry Jurisdiction
CYGNUS, INC. and MELLON INVESTOR SERVICES LLC Rights Agent Rights Agreement Dated as of October 17, 2005Rights Agreement • October 17th, 2005 • Cygnus Inc /De/ • Measuring & controlling devices, nec • New York
Contract Type FiledOctober 17th, 2005 Company Industry JurisdictionAgreement, dated as of October 17, 2005, between Cygnus, Inc., a Delaware corporation (the “Company”), and Mellon Investor Services LLC (the “Rights Agent”).
EXHIBIT 4.6 FORM OF COMMON STOCK PURCHASE WARRANT - REEDLAND CAPITAL PARTNERS THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, OR ANY STATE SECURITIES LAWS. THEY MAY NOT BE SOLD OR OFFERED FOR SALE EXCEPT PURSUANT TO AN...Cygnus Inc /De/ • May 10th, 2001 • Pharmaceutical preparations
Company FiledMay 10th, 2001 Industry
EXCLUSIVE LICENSE AGREEMENTExclusive License Agreement • March 22nd, 2000 • Cygnus Inc /De/ • Pharmaceutical preparations • California
Contract Type FiledMarch 22nd, 2000 Company Industry Jurisdiction
RECITALSIndemnification Agreement • March 27th, 2001 • Cygnus Inc /De/ • Pharmaceutical preparations • Delaware
Contract Type FiledMarch 27th, 2001 Company Industry Jurisdiction
EXHIBIT 10.47 [CONFIDENTIAL TREATMENT REQUESTED] MANUFACTURING AND SUPPLY AGREEMENTManufacturing and Supply Agreement • January 20th, 2000 • Cygnus Inc /De/ • Pharmaceutical preparations • New Jersey
Contract Type FiledJanuary 20th, 2000 Company Industry Jurisdiction
RECITALS:Lease Termination Agreement • December 17th, 2004 • Cygnus Inc /De/ • Measuring & controlling devices, nec
Contract Type FiledDecember 17th, 2004 Company Industry
WITNESSETHCertain • October 17th, 2000 • Cygnus Inc /De/ • Pharmaceutical preparations • Delaware
Contract Type FiledOctober 17th, 2000 Company Industry Jurisdiction
BETWEEN CYGNUS, INC. ANDSupply and Distribution Agreement • January 23rd, 1997 • Cygnus Inc /De/ • Pharmaceutical preparations • California
Contract Type FiledJanuary 23rd, 1997 Company Industry Jurisdiction
PRODUCT SUPPLY AGREEMENTProduct Supply Agreement • March 22nd, 2000 • Cygnus Inc /De/ • Pharmaceutical preparations • California
Contract Type FiledMarch 22nd, 2000 Company Industry Jurisdiction
EXHIBIT 10.302 LICENSE AGREEMENT AMENDMENT This amendment ("Amendment") is effective this 23 day of April 1998, between The Regents of the University of California, a California corporation having statewide administrative headquarters at 300 Lakeside...License Agreement • March 22nd, 2000 • Cygnus Inc /De/ • Pharmaceutical preparations
Contract Type FiledMarch 22nd, 2000 Company Industry
AMENDMENT NO. 4 TO THE STRUCTURED EQUITY LINE FLEXIBLE FINANCING-SM- AGREEMENTCygnus Inc /De/ • October 31st, 2000 • Pharmaceutical preparations • New York
Company FiledOctober 31st, 2000 Industry Jurisdiction
CYGNUS, INC.Loan and Security Agreement • November 16th, 1998 • Cygnus Inc /De/ • Pharmaceutical preparations • California
Contract Type FiledNovember 16th, 1998 Company Industry Jurisdiction
RECITALSQuality Agreement • December 23rd, 2003 • Cygnus Inc /De/ • Measuring & controlling devices, nec • California
Contract Type FiledDecember 23rd, 2003 Company Industry Jurisdiction
EXHIBIT 1.1 STRUCTURED EQUITY LINE FLEXIBLE FINANCING AGREEMENT STRUCTURED EQUITY LINE FLEXIBLE FINANCING AGREEMENT dated as of March 23, 2001 (the "Agreement"), between Cripple Creek Securities, LLC (the "Investor"), and Cygnus, Inc., a corporation...Financing Agreement • April 9th, 2001 • Cygnus Inc /De/ • Pharmaceutical preparations • New York
Contract Type FiledApril 9th, 2001 Company Industry Jurisdiction
ARTICLE I. PURCHASE AND SALE OF DEBENTURES AND WARRANTSConvertible Debenture and Warrant Purchase Agreement • August 16th, 1999 • Cygnus Inc /De/ • Pharmaceutical preparations • New York
Contract Type FiledAugust 16th, 1999 Company Industry Jurisdiction