0001104659-02-006271 Sample Contracts

AMENDED AND RESTATED LOAN AGREEMENT
Loan Agreement • November 15th, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances • Massachusetts

Reference is hereby made to that certain Loan Agreement (the “Prior Loan Agreement”), dated as of September 6, 2002, by and among Ostex International, Inc., a Washington corporation (the “Borrower”), and Inverness Medical Innovations, Inc., a Delaware corporation (the “Lender”). This AMENDED AND RESTATED LOAN AGREEMENT (this “Loan Agreement”) dated as of October 10, 2002, is entered into by and among the Borrower and the Lender to amend and restate the Prior Loan Agreement in its entirety. Capitalized terms used herein without definition shall have the meanings ascribed to such terms in the Merger Agreement (as defined herein).

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AMENDMENT AGREEMENT
Amendment Agreement • November 15th, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances

This Amendment Agreement between Ostex International, Inc. (the “Company”), a Washington corporation, and Thomas A. Bologna (“Executive”) is dated and entered into as of February 10, 1998.

AMENDMENT TO EXCLUSIVE LICENSE AGREEMENT BETWEEN THE WASHINGTON RESEARCH FOUNDATION AND OSTEX INTERNATIONAL, INC.
Exclusive License Agreement • November 15th, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances

This Amendment is made as of September 5, 2002 (the “Effective Date”), by and between the Washington Research Foundation, a not-for-profit Washington corporation (“WRF”), and Ostex International, Inc., a Washington corporation (“Ostex”). This Amendment amends the Exclusive License Agreement by and between the WRF and Ostex made on February 10, 1994 (“Agreement”).

AMENDMENT NO. 2 TO EMPLOYMENT AGREEMENT
Employment Agreement • November 15th, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances

This Amendment No. 2 between Ostex International, Inc. (the “Company”), a Washington corporation, and Thomas A. Bologna (“Executive”) is dated and entered into as of January 16, 2002.

AMENDMENT NO. 3 TO EMPLOYMENT AGREEMENT
Employment Agreement • November 15th, 2002 • Ostex International Inc /Wa/ • In vitro & in vivo diagnostic substances

This Amendment No. 3 between Ostex International, Inc. (the “Company”), a Washington corporation, and Thomas A. Bologna (“Executive”) is dated and entered into as of July 9, 2002.

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