0001104659-03-010399 Sample Contracts

INDEMNIFICATION AGREEMENT
Indemnification Agreement • May 15th, 2003 • Transkaryotic Therapies Inc • Biological products, (no disgnostic substances) • Delaware

This Agreement is made as of the 30th day of April 2003, by and between Transkaryotic Therapies, Inc., a Delaware corporation (the “Corporation”), and Michael J. Astrue (the “Indemnitee”), a director and an officer of the Corporation.

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INDEMNIFICATION AGREEMENT
Indemnification Agreement • May 15th, 2003 • Transkaryotic Therapies Inc • Biological products, (no disgnostic substances)

This Agreement is made as of the 13th day of March 2003, by and between Transkaryotic Therapies, Inc., a Delaware corporation (the “Corporation”), and Daniel E. Geffken (the “Indemnitee”), an officer of the Corporation.

RETENTION AGREEMENT
Retention Agreement • May 15th, 2003 • Transkaryotic Therapies Inc • Biological products, (no disgnostic substances) • Massachusetts

This Retention Agreement is made as of March 13, 2003 by and between Transkaryotic Therapies, Inc., a Delaware company (the “Company”), and Daniel E. Geffken (the “Executive”).

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions.
License Agreement • May 15th, 2003 • Transkaryotic Therapies Inc • Biological products, (no disgnostic substances)

WOMEN’S AND CHILDREN’S HOSPITAL, a non-profit institution incorporated in South Australia and of 72 King William Road, North Adelaide, South Australia (“Licensor”);

EMPLOYMENT AGREEMENT
Employment Agreement • May 15th, 2003 • Transkaryotic Therapies Inc • Biological products, (no disgnostic substances) • Massachusetts

AGREEMENT, dated as of April 30, 2003, between Transkaryotic Therapies, Inc., a Delaware corporation (the “Company”), and Michael J. Astrue (the “Executive”).

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