0001104659-03-025799 Sample Contracts

FOURTH LOAN MODIFICATION AGREEMENT
Loan Modification Agreement • November 12th, 2003 • Arqule Inc • Pharmaceutical preparations

This Fourth Loan Modification Agreement (“this Agreement”) is made as of September 3, 2003 between ArQule, Inc., a Delaware corporation (the “Borrower”) and Fleet National Bank (the “Bank”). The Bank is the successor by merger to the entity formerly known as “Fleet National Bank” (“Old FNB”). For good and valuable consideration, receipt and sufficiency of which are hereby acknowledged, the Borrower and the Bank act and agree as follows:

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EMPLOYMENT AGREEMENT
Employment Agreement • November 12th, 2003 • Arqule Inc • Pharmaceutical preparations • Massachusetts

This Employment Agreement (the “Agreement”) dated as of September 5, 2003 (the “Execution Date”) is made by and between ArQule, Inc., a Delaware corporation (the “Company”) with its principal offices at 19 Presidential Way, Woburn, Massachusetts 01801, and Chiang J. Li, M.D. (“Executive”) whose current principal residential address is 61 Gardner Street, West Roxbury, Massachusetts 02132.

AGREEMENT AND PLAN OF REORGANIZATION
Reorganization Agreement • November 12th, 2003 • Arqule Inc • Pharmaceutical preparations • Delaware

AGREEMENT AND PLAN OF REORGANIZATION (“Reorganization Agreement” or “Agreement”) dated as of July 16, 2003, by and between ArQule, Inc. (“ArQule”), a Delaware corporation having its principal executive office at 19 Presidential Way, Woburn, MA 01801, and Cyclis Pharmaceuticals, Inc. (“Cyclis”), a Delaware corporation having its principal executive office at 333 Providence Highway, Norwood, MA 02062.

AGREEMENT AND PLAN OF MERGER OF CYCLIS PHARMACEUTICALS, INC. WITH AND INTO ARQULE, INC.
Merger Agreement • November 12th, 2003 • Arqule Inc • Pharmaceutical preparations

AGREEMENT AND PLAN OF MERGER (“Plan of Merger”) dated as of July 16, 2003, by and between ArQule, Inc. (“ArQule”), a Delaware corporation having its principal executive office at 19 Presidential Way, Woburn, MA 01801, and Cyclis Pharmaceuticals, Inc. (“Cyclis”), a Delaware corporation having its principal executive office at 333 Providence Highway, Norwood, MA 02062.

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